Skin tuberculosis should be regarded as a part of systemic infection, and 3 ~ 4 kinds of anti-tuberculosis drugs should be used early, in sufficient amount, regularly, in the whole process, in order to ensure the curative effect and delay or prevent the drug resistance of Mycobacterium tuberculosis. Cooperate with surgical treatment when necessary.

1. systemic therapy: first-line anti-tuberculosis drugs include rifampicin, isoniazid, pyrazinamide, ethambutol, rifapentine and rifabutin; Second-line anti-tuberculosis drugs include cycloserine, ethionine, propylthioisoniazid, aminobenzoic acid, tendril mycin, erythromycin, streptomycin, amikacin, kanamycin, levofloxacin, gatifloxacin and moxifloxacin.

The standard half-year treatment plan for adult skin tuberculosis is: taking rifampicin (10mg/kg), isoniazid (5mg/kg), pyrazinamide (35mg/kg) and ethambutol (15 mg/kg) orally in the first two months; After 4 months of continuous treatment, rifampicin and isoniazid were taken orally. If the patient is not resistant to isoniazid, ethambutol may not be added. People infected with HIV need longer continuous treatment, at least more than 7 months.

2. Surgical treatment: early small lesions of lupus erythematosus or verrucous skin tuberculosis can be surgically removed. Surgical treatment is also effective for cutaneous tuberculosis with lymphadenopathy. The scars left by lupus erythematosus can be treated by plastic surgery.