The most famous king of Guishuang Dynasty was Ganeshega. He is also famous for spreading Buddhism. During the Ganeshega period, the territory of Guishuang Empire was very large, including Uzbekistan, Kazakhstan, Tajikistan and most parts of northern India in Central Asia. The rule of Guishuang dynasty lasted until Bossasan dynasty ruled Zuchaslo.

In the 3rd century, Guishuang became a vassal state of Sassanian dynasty.

Under the rule of foreigners, ancient India also broadened the horizons of Indians, especially in the era of Guishuang Dynasty, which not only expanded the trade with western Greece, Rome and eastern China, but also strengthened the cultural exchanges between Greece, Rome and China. At that time, the silk trade was closely related to Buddhism, so it can be said that silk was a commodity related to Buddhism. "Early Mahayana Buddhist scriptures, such as memorabilia or the Lotus Sutra, not only encouraged believers to decorate pagodas with silk, but also made a wish that even if they only donated a piece of silk, they would accumulate great virtues and seek happiness in this life and the next. It is popular to decorate pagodas with colored silk and jewels. After Central Asia and China, it developed into a colorful flag, which grew to hundreds of feet in centuries. When Song Yun and Sheng Hui of the Northern Wei Dynasty went to the Western Seas as special envoys of the Northern Wei Dynasty, they brought 1000 hundred-foot-long flags, silk sachets and 2,000 shorter colored flags. Buddhist consumption is an important part of the silk trade. " Silk trade has also promoted cultural exchanges. The filament dance and lion dance, which were popular in ancient China, were influenced by the Buddhist art accompanying the silk trade. Short towels worn by Gandhara-colored Buddhists flying in the Thousand Buddha Cave in Qizil, Xinjiang may also be a reflection of the silk trade in Gandhara.