Sjogren's syndrome is a chronic autoimmune disease that invades lacrimal gland, salivary gland and other diseases, also known as autoimmune exocrine gland disease. Mainly manifested as keratoconjunctivitis sicca, xerostomia or rheumatoid arthritis and other rheumatic diseases. It can affect other systems, such as respiratory system, digestive system, urinary system, blood system, nervous system, muscles and joints, resulting in multi-system and multi-organ damage. Only this disease also occurs in other autoimmune diseases. Primary Sjogren's syndrome is secondary to immune system diseases such as rheumatoid arthritis, systemic scleroderma and systemic lupus erythematosus. Diseases with high incidence mostly occur in women over 40 years old.
The etiology of Sjogren's syndrome is still unknown, but it is generally believed that it is related to the following factors at home and abroad:
Autoimmunity of 1: Sjogren's syndrome reflects the cellular inhibitory dysfunction of highly hyperthyroidism B lymphocytes and T lymphocytes, and many autoantibodies have been detected, such as antinuclear antibodies, rheumatoid factors, anti-RNP antibodies, anti-SSA antibodies, anti-SSB antibodies and gammaglobulinemia.
2. Genetic basis; In the determination of immune genes, medical scientists found that HLA-DR3 and B8 are closely related to Sjogren's syndrome, because different races and different populations, such as Western Europe, are related to HLA-B8, DR3, DW52, Japan and HLA-DR53.
3. Virus infection: At least three viruses, such as Epstein-Barr virus, cytomegalovirus, HIV and Sjogren's syndrome, Epstein-Barr virus can stimulate the proliferation of B cells and immunoglobulin.
symptom
Dry mouth constellation:
(1) Dry mouth: More than 80% of patients have dry mouth symptoms, which are manifested as decreased saliva secretion, dry mouth, no saliva or vomiting, inability to swallow dry food, and need to drink water to swallow meals.
(2) Reduce dental caries: The driest syndrome patients lose the saliva that moistens, washes and nourishes their teeth due to the secretion of salivary glands, and the gradually blackened teeth and tooth blocks close, leaving only residual roots and residues. Due to the occurrence of this situation and the severity of systemic dental caries, it is called "rampant dental caries". enlargement?of parotid gland
(3): About 40% patients have a history of parotid gland enlargement, and they have bilateral seizures several times a year, and they have a slight cold or fatigue, which leads to seizures.
(4) Special tongue picture: We found that in the typical clinical manifestations of Sjogren's syndrome, the tongue picture has the following characteristics: the tongue is pale crimson, reddish purple or dark red, tender red as a mirror, or criss-crossing gullies with cracks, no body fluid and no coating, and the tongue quality is difficult to shorten and prolong.
2, eye performance:
The secretion function of lacrimal gland is decreased, and patients feel dry eyes, little or no tears, and tears in mood. There is a rubbing or burning sensation of intraocular foreign bodies, heavy eyelids, conscious front curtain occlusion, photophobia, eye pain, recurrent squabbles and conjunctivitis. In severe cases, phlegm, cough and vomiting, dry stool, vaginal dryness and sexual pain may occur, so pannus, corneal perforation and iritis may occur.
3, dry skin, dry nose without tears. BR/>；
cheque
1, routine hematuria. 2.x-ray examination.
The length of the positive filter paper soaked in 3 Schivmer test is definitely abnormal: normal 1.5 mm 5mm/5min. Or corneal staining test positive: corneal drop rose red, slit lamp examination, unilateral >; 10 color point is abnormal.
4, lip biopsy showed that /5 minutes ≥ 1. Lymphocyte infiltration in the lesion was 4 mm Lymphocytes ≥50 gather into a furnace.
5, saliva flow is reduced, there is no stimulation of saliva flow.
6. Anti-SS-A or anti-SS-B antibody.
treat cordially
Corticosteroids and immunosuppressants have certain curative effects without special treatment, but long-term application will have serious consequences and should be used with caution. Can be used to prevent excessive hormones caused by tuberculosis, anti-tuberculosis drugs (such as rifampicin).
Sjogren's syndrome patients are characterized by chun yin deficiency as the basis, dryness and heat as the standard, and are characterized by dryness and heat in eyes, mouth, skin and vagina, and body fluid injury.
Therefore, the diet of patients with Sjogren's syndrome should be sweet, cool and moist, and they should eat more foods that nourish yin and clear heat, such as soft foods such as lobster sauce, loofah, celery, cauliflower, day lily, gouqi head, celery, mussel, turtle, and fruits such as watermelon, orange, fresh pear, fresh lotus root, etc., to quench thirst, and dry mouth can often contain dark plum and honey fruit.
Avoid eating spicy and hot drinks and food, in case of disability allowance, to help dry will aggravate the condition.
Eat spicy, fragrant, dry and warm products, such as wine, tea, coffee, all kinds of fried foods, mutton, dog meat, venison, ginger, onion, garlic, pepper, pepper, fennel and non-smoking areas.
For patients with Sjogren's syndrome with a long course of disease, there is no strict taboo to avoid correct diet at the same time. This year's unfavorable situation will affect the absorption of nutrients.
In short, the food should be fresh meat and vegetables, eat less and eat more meals, have a proper diet and taste, and ensure adequate nutrition.
Joint pain can be treated with acupuncture and moxibustion, dry skin scrubbing solution to relieve syrup, and dry nasal cavity dripping with normal saline. Avoid using oily lubricants, avoid inhaling lubricants that hinder sexual life due to lipomatous pneumonia and vaginal dryness, and pay attention to keeping the vulva clean and hygienic.