2. Hydroxyapatite is a new bone substitute. Its advantage is that it does not need to be prefabricated into various shapes like cancellous bone, calcium phosphate ceramics and other materials, but can be simply injected into the bone defect and solidified in situ to adapt to the bone defect. It is widely used because of its excellent biocompatibility, non-toxicity, non-irritation, non-rejection, non-aging, non-sensitization, non-carcinogenicity and chemical combination with bone tissue.