Li Shizhen was a famous doctor in Ming Dynasty. He has been interested in medical care since he was a child, aiming at saving people from diseases. Influenced by his father, Li Shizhen read more medical books and paid attention to the combination of practice and knowledge. Li Shizhen has been engaged in medical research all his life. In order to correct the mistakes recorded in the materia medica before the Ming Dynasty and put it into a complete materia medica, Li Shizhen began a field investigation for decades. When Li Shizhen went out, he always carried a basket, wore sandals, took a pen and paper, and started a long journey with his son and students. Therefore, Li Shizhen not only discovered many previously undiscovered herbs, but also figured out the difficulties of many drugs, such as the toxicity test of Datura flower, which not only understood the performance of Datura flower, but also developed an antidote and so on. Li Shizhen also made some investigations and studies on zoology, such as the living habits of pangolin and the study of Agkistrodon acutus, which not only supplemented the records in Materia Medica, but also developed the medicinal use of Agkistrodon acutus. Moreover, Li Shizhen also dabbled in mineral medicine to some extent. He visited several mines and found that lead is toxic, not a non-toxic substance recorded in previous herbal books, and "mercury" is not an elixir of life. Taking it can't live forever, but it will cause cancer and toxic substances all the year round, breaking the feudal theory. Li Shizhen traveled to many places, visited Wan Li, climbed mountains and mountains, and finally completed the Compendium of Materia Medica. This Compendium of Materia Medica is a summary of China's pharmacology before the Ming Dynasty, attracting worldwide attention. It not only affects the medical field, but also contributes to other disciplines such as biology and chemistry. Darwin also called this book "the encyclopedia of ancient China". Compendium of Materia Medica has also been translated into many languages and spread all over the world. Li Shizhen's other medical works, such as "Frequency Lake Pulse", have important guiding significance to the clinical practice of traditional Chinese medicine, which can be described as classic works of traditional Chinese medicine and have far-reaching influence in the field of traditional Chinese medicine.