Alias: Luo Fei Kao Xi, Wanluo, Wanluo; Indications of rofecoxib: It can be used to treat proliferative osteoarthropathy and rheumatoid arthritis. It is also used to relieve pain and treat primary dysmenorrhea. Including all kinds of postoperative pain after dental and plastic surgery. ; Pharmacological effects of rofecoxib: This drug belongs to non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs can inhibit two subtypes of cyclooxygenase (COX-1 and COX -2) to varying degrees. Drugs that inhibit cyclooxygenase-1 can cause adverse reactions in gastrointestinal tract and kidney, and their antiplatelet activity is also related to the inhibition of cyclooxygenase-1. On the contrary, drugs that inhibit cyclooxygenase -2 mainly produce anti-inflammatory and analgesic effects, and their analgesic/anti-inflammatory effects are similar to those of traditional non-steroidal anti-inflammatory drugs, but the incidence of adverse reactions is reduced. The drug is a specific cyclooxygenase -2 (COX-2) inhibitor, so it has analgesic/anti-inflammatory effects, and the incidence of gastrointestinal adverse reactions is less. The mechanism of action is the same as Selib. Give this product 12.5mg or 25mg every day. Its curative effect can be compared with ibuprofen 800 mg, three times a day or diclofenac 50 mg, three times a day. Continue to take vioxx &; The relative risk of some cardiovascular events (such as heart attack and stroke) in reg patients is increased. On September 30th, 2004, Merck announced that it would voluntarily withdraw its drug Vioxx & Reg (rofecoxib)