Collagen has the following special properties, so it can play a variety of biological functions:

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2. Support and protection

3. Biomechanical properties-strength, toughness and ductility

4. Control molecular permeability

5. Promote wound healing and tissue repair.

6. Biological functions of ganglion cells and tissues

Application of collagen

Biomedical materials

Artificial skin, artificial esophagus, artificial trachea, burn protection film

Drugs and medical uses

Plastic surgery, slow-release drugs, bladder incontinence drugs, etc.

cosmetics

Skin cream (cream), (water retention), conditioner, etc.

food industry

Health food and beverage

Chemical raw material

Paint, plastic, ink, etc.

Research purposes

Reagent for cell culture, biosensor, bioreactor carrier membrane and platelet aggregation

other

Collagen, combined with resin, is the material to repay cigarette filters and filters.

The use of collagen

Beauty medicine

Repair of facial skin tissue, such as eliminating wrinkles and filling holes.

Plastic surgery modeling

Rhinoplasty, cheek augmentation, chin reconstruction, eye bags removal, lip beauty and earlobe enlargement.

clinical treatment

Treatment of urinary incontinence, vocal cord repair, fracture regeneration, artificial skin, alveolar reconstruction, tissue regeneration of periodontal disease.

At present, many medical research units are trying to make collagen into clinical experiments with different uses, such as covering the wounds of burn patients with treated pigskin rich in collagen; Using the extracted collagen can promote the migration and growth ability of epidermal cells, greatly shorten the time of wound healing and improve the survival ability of burn patients. Collagen can be used as biomedical materials, such as orthopedics, plastic surgery, dermatology, cardiovascular surgery, neurosurgery, dentistry and ophthalmology, and has a bright future in clinical application because of its characteristics of protecting and supporting the tensile strength of human tissues and bones, as well as its viscosity and elasticity.

Collagen products for biomedical use

Collagen can be extracted and purified from animal tissues, and then made into various products for biomedical applications.

(1) solution for injection

Suitable for filling soft tissue defects, such as small needle beauty, repairing skin pits and wrinkles.

(2) the shape of crude fiber

Collagen can be used as surgical suture. Because of its high biocompatibility, it can be absorbed by the body and can avoid the procedure of suture removal. Bovine tendons and ligaments, after proper chemical modification, can replace short list bones and ligaments caused by sports injuries in clinical medicine.

(3) colloid

It can be used for drug delivery and tissue filling in specific parts of defects, so as to achieve the purpose of shaping and repairing skin or organs and tissues.

(4) Tubular shape

These products can be pre-coated with anticoagulant or filled with whole blood vessel cells, and can also be used as blood vessel replacement materials: in neurosurgery, tubular collagen is considered as an excellent medium to guide peripheral nerve regeneration, protein.

(5) Film or sheet shape

Collagen shield used in ophthalmology can accelerate the repair of corneal epithelial cells, eliminate the release of antibacterial, anti-inflammatory and anticoagulant drugs, and effectively alleviate corneal edema. In dental application, collagen membrane is placed on the surface of dental implant materials to improve its biocompatibility, or filled collagen membrane is used to promote the recombination and growth of periodontal tissue, alveolar bone and periodontal ligament, so that teeth can have better contact with surrounding tissues.

(6) Porous flaky sponge or fibrous sponge.

This is the product of collagen freeze-drying, which can be used as hemostatic, wound dressing, tissue gasket and artificial crescent-shaped tablet software in medicine. Because of spongiform inflammation, it can be used as a substitute for meningeal injury in surgery.

(7) Adsorption or combination on the surface of synthetic materials.

Collagen bound or adsorbed on the surface of synthetic materials with valence of * * * is used to improve the biocompatibility of products. For example, the wound dressing of plastic surgery is collagen adsorbed on nylon surface. Because nylon is a synthetic polymer material, it is not easily absorbed by living bodies, so it is only a temporary dressing.

(8) Composite materials

Mainly utilize that good biocompatibility of collagen and the mechanical advantages of synthetic material such as polyurethane or polyester, and can form a compound with these materials after adding collagen. The composite of collagen and ceramic material can be used as bone filler.

(9) Other products

For example, chemically modified pig heart valves or bovine pericardium cut into heart valves can be used as artificial valves for human transplantation, which has a history of 20 ~ 30 years.