The initial therapeutic drugs were divided into four types: concentration 0, concentration 1, concentration 2 and concentration 3, each of which was 4.5ml/ bottle. Maintain therapeutic agent concentration level 3.
Usage and dosage: Under aseptic conditions, the doctor will use a short trocar to slowly and deeply inject subcutaneously at the elbow of the extended side of the upper arm. Slight lifting of skin folds helps to penetrate deep under the skin. Press the injection site for 5 minutes after injection. Next time, inject in the other arm.
Treatment cost: it should be free treatment. Details are as follows.
Allergo products "allergen injection" used in major hospitals across the country are suspected of illegal sales. The US Food and Drug Administration only approved the drug for clinical trials in China. According to the regulations, drugs for clinical trials should be provided free of charge by hospitals and paid to experimenters. However, the drug is widely sold all over the country, and not only does it not pay the experimenter, but it charges the experimenter a high drug fee.
Initial treatment:
A. For seasonal allergens (such as pollen), the treatment must be started before the season, that is, about 6 months before the expected pollen season, and ended about 2 weeks before the pollen floats (note that the early spring trees such as hazel and alder have pollen floating in 1 month or even earlier).
B, for non-seasonal allergens (such as mites), try to start when the symptoms are mild.
The initial treatment starts with the minimum dose of the lowest concentration (1 grade) (it can also start from grade 0). For children and highly sensitive patients, start from level 0 (110 equal to the concentration of level 0). During dose escalation, the injection interval shall not be less than 7 days and shall not exceed 14 days.
To be on the safe side, if the initial treatment is interrupted for 2-4 weeks, the injection amount for continuing treatment shall not exceed half of the last dose; If the initial treatment is interrupted for more than 4 weeks, it must be restarted with the minimum dose of the lowest concentration (1 level or 0 level).
The absolute maximum dose is 1.0ml, but the maximum dose is different for each patient. After reaching the maximum dose per patient, the injection interval can be gradually extended to 4-6 weeks until about 2 weeks before the expected pollen season begins.
Maintenance treatment:
1, for seasonal allergens (such as pollen), choose one of the following two methods for maintenance treatment:
Method 1: In the pollen floating season, due to the invasion of natural allergens, the treatment is suspended. Leave in late autumn.
① Start from the initial treatment concentration (0), 1, 2 and 3. This method is beneficial to highly sensitive patients. According to the medical history after diagnosis, the allergen composition was determined.
② Start again with 5% of the final dose. The dose was doubled about every 14 days until the maximum individual dose was reached. At this time, the maintenance treatment was carried out with the concentration of grade 3. This treatment is only suitable for patients who have reached and can tolerate the maximum individual dose of concentration level 3 in the last flowering period.
Method 2: Maintenance treatment is also carried out at flowering stage, and 5%-20% of the highest dose can be injected every 2 weeks. Then the injection interval was gradually extended to 4 weeks. After the flowering period, the above-mentioned reduction treatment was started, and then the dose was increased every two weeks 1 time until the maximum individual dose was reached. Then the injection interval is gradually extended to 4-6 weeks.
2. For non-seasonal allergens (such as dust mites), gradually extend the injection interval to about 4-6 weeks, and give this amount as a booster dose within one year after reaching the maximum individual dose.
A, the first dose of new packaging shall not exceed 20% of the last dose, and then the dose shall be increased to the maximum individual dose. According to the patient's sensitivity and tolerance to the last dose, the injection interval time is determined.
B, during the maintenance treatment, if the scheduled injection time exceeds 2 weeks, the continued treatment dose shall not exceed half of the last dose; More than 2 weeks, the dose shall not exceed 5% of the last dose; If it is more than one year, the treatment must be restarted (see "Initial Treatment").
Increase the dose on the basis of patients' good tolerance to the last dose; If the last dose is not well tolerated, use the last dose or reduce the dose.
It can be administered according to the following guidelines:
① Strong local reaction: repeated use of the last tolerated dose.
② Mild systemic reaction: reduce the last dose by 2-3 grades.
③ Severe systemic reaction: restart with 1 (or 0) concentration.
According to the course and severity of allergic reaction, make a decision to continue treatment!
Subsequently, during the maintenance treatment, the dose can be slightly increased while the injection interval remains unchanged.
The total course of treatment is generally 2-3 years; If possible, the symptoms are obviously improved or disappeared and then treated for one year.