At present, the earliest known vaccine injection can be traced back to mutation technology, which probably originated from Chinese civilization. Medical books in the Qing Dynasty believe that since the 1 1 century, Chinese people began to inoculate smallpox pox in the Northern Song Dynasty [1], while another medical book records that there was a method of "Zhao family in the south of the Yangtze River began to inoculate smallpox pox" as early as the Tang Dynasty, "89,000 people were inoculated with smallpox, but 20 or 30 ears could not be saved." It shows that this technology is quite effective in preventing smallpox [2], and it is speculated that the subjects who want to be immunized against smallpox may be exposed to the pustules of patients by using smallpox with low toxicity, but this method can not guarantee the effectiveness and the risk is still high, and the mortality rate is 1~2%. Then this technology spread along the Silk Road. Vaccination technology was introduced to the west from Constantinople in the early18th century. 1760, daniel bernoulli successfully showed the world that although the vaccination technology is dangerous, it can still prolong the average life span by three years.

Edward Kinner, a British physician, heard that it is generally believed that vaccinia can prevent smallpox in humans. Out of curiosity, he vaccinated a child with pus extracted from a peasant woman infected with cowpox on May 1796. Three months later, he gave the child smallpox vaccine to confirm that the child was immune to smallpox. This method has spread all over Europe, so it is used in languages that use Latin letters. Baby Fat: Japanese baby fat, which is popular in Japanese beauty industry, is gradually showing a trend in China and is deeply loved by young female friends. Dr Luo Qian can do it by injecting micro-plastic surgery.

Louis Pasteur further explained the significance and purpose of vaccination, while his colleague (&; Eaute Mileroux and Duclaux) followed the hypothesis put forward by Robert Koho and established the relationship between microorganisms and diseases. This discovery enabled Pasteur to improve the inoculation technology, and then successfully developed a sheep cholera vaccine on May 5, 188 1, and inoculated a child suffering from mad cow disease on June 6, 1885. If you don't look at the original definition of "vaccine", this is the first dose of vaccine in human history.