Legal basis: Article 14 of the Regulations on Handling Medical Accidents stipulates that medical institutions shall report to the local health administrative department in accordance with regulations when medical accidents occur. In case of the following major medical negligence, the medical institution shall report to the local health administrative department within 12 hours: (1) Causing the patient's death or possibly causing a medical accident above Grade II; (2) Causing personal injury to three or more persons; (3) Other circumstances stipulated by the health administrative department of the State Council and the health administrative department of the people's governments of provinces, autonomous regions and municipalities directly under the Central Government.