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Clinical application of botulinum toxin
After understanding the structure, function and mechanism of action of botulinum toxin in clinic, human beings began to use botulinum toxin as an effective drug. Botulinum toxin is used to treat eyelid spasm, spastic torticollis, spastic dysphonia and other diseases.

1992 someone tried to introduce botulinum toxin injection wrinkle removal method into the treatment of cosmetic medicine, which is what we call wrinkle removal. Botox rhytidectomy is also called biotin rhytidectomy, and the trade name of Botox A is "Botox".

Botox, which is popular in the beauty industry these days, can be said to be a kind of plastic surgery that takes neither time nor surgery, which makes many beauty lovers eager to try, but wait a minute ... The British version of ELLE reports that any plastic surgery is outdated for the entertainment and entertainment circles, and the most in-depth appearance in the new century should be the most natural.

Botox, which is used to shape facial lines, is a neurotoxin, which can inhibit the secretion of nerve conduction substances at the neuromuscular junction, make muscles paralyze and atrophy, and thus achieve the function of shaping lines. Therefore, it can effectively address the symptoms of jaw width caused by the over-development of facial masseter muscles. There are many reasons for facial obesity and width. Among them, patients with well-developed facial masseter muscles are suitable for Botox injection. However, if it is caused by other reasons, such as excessive fat or congenital bone width, liposuction or plastic surgery can be taken according to the situation.

Creating a calf leg shape is the same as Botox's face-lifting principle. Botulinum injection can also effectively aim at the phenomenon of thick calves caused by muscular calves. So as to achieve the effect of correcting the leg shape. During the treatment, the injection is selectively performed in the gastrocnemius located at the outermost part behind the calf, so that muscle strength can be eliminated and the leg circumference of the calf can be reduced.

Farewell to hyperhidrosis Botox has another unknown function, that is, it can effectively treat hyperhidrosis. Acetylcholine can be cut off at the nerve end by injecting Botox. So as to inhibit sweat secretion. During the treatment, Botox was injected under both axillae for only 10 minutes. Can effectively relieve hyperhidrosis. Moreover, patients do not have much pain during the treatment, and there is no need to worry about leaving scars. Generally speaking, the effect of each injection can last for about 6 months, so you need to stick to it!

Botox injection wrinkle removal has been widely used all over the world, with simple operation, no influence on work and no complications. Botox has an obvious effect on eliminating wrinkles on the head, which is much better than the general wrinkle removal method. And simple, fast and green. It only takes 5 minutes, leaving no trace after completion, which will not affect the work, and the effect will appear after 2 or 3 days. Botox injection has a quick and obvious wrinkle removal effect. The effect of the first injection usually lasts for 6 to 12 months, and the second injection lasts longer and can be repeated.

Wrinkle removal and face-lifting aging are natural laws, and no panacea has been found to prevent and prevent aging. The United States began to study and apply Botox to treat facial wrinkles from 1980, and achieved good results. This method quickly became popular in Europe and America, spread all over the world and was greatly favored by Hollywood stars. According to relevant data, the annual growth rate of botulinum toxin A beauty is as high as 1.42%. Some experts predict that botulinum toxin A will become "the main method of cosmetic wrinkle removal in 2 1 century".

Face-lifting needle also refers to Botox injection. Compared with botulinum toxin used for wrinkle removal, the difference between them often lies in the different dosage. Botulinum toxin drugs can block the nerve impulses of nerves and muscles, paralyze the over-developed muscles to make them contract, and use paralyzing muscles to achieve the purpose of prohibiting atrophy, thus making the originally hypertrophy muscles atrophy. Botox face-lifting is time-sensitive, but after repeated and continuous Botox injections, the masseter muscle can be permanently reduced due to long-term paralysis, making the face-lifting more stable and thorough, and finally achieving the goal of permanent face-lifting. Principles of treatment

Botulinum botulinum type A is a neurotoxin, which is injected into muscles that cause wrinkles and acts on peripheral motor nerve endings and neuromuscular junctions, namely synapses, inhibiting the release of neurotransmitters in presynaptic membranes and blocking the release of acetylcholine, thus reducing muscle tension or paralysis, and wrinkles gradually disappear, thus achieving the effect of treating facial wrinkles. Botox wrinkle removal does not need any sedative or local anesthetic, and it can continue normal activities immediately after Botox wrinkle removal treatment. Botox wrinkle removal can be reserved during lunch break, which does not affect the work arrangement at all.

Muscle relaxation occurred 2-3 days after injection, and reached its peak on 10- 14 days, and the muscles were completely relaxed and paralyzed. At this time, the effect is the best, lasting for 5- 10 months, gradually weakening and disappearing, and the average injection is three times a year. As long as it is facial obesity caused by masseter hypertrophy, the effect of face-lifting with face-lifting needle is very obvious under the condition of strict doctor's advice. One week after the injection of face-lifting needle, it can be observed that the face gradually becomes thinner, achieving the effect of "face-lifting".

The effect of face-lifting needle is recoverable, that is to say, in theory, it takes three to six months to inject again to maintain the effect. Some people can keep it for a long time with 2-3 injections. If you want to delay the recovery of masseter muscle, you should eat less hard and tough food. But clinically, we found that some people don't need to inject again after two or three times to maintain the effect, which means that Botox has a long-term impact on Chinese characters' faces. The reason is that during the curative effect of Botox, the human body cannot overuse the masticatory muscles. If we can get rid of the habit of overusing masticatory muscles, after the curative effect of Botox, the thinner masticatory muscles will not hypertrophy and proliferate again.

Comparison of the effects of Botox before and after wrinkle removal, as shown in the figure: Botox face-lifting is to inject a face-lifting needle into the masseter muscle to reduce the occlusion and achieve the effect of face-lifting. Botox is a biological product. Because of its nerve blocking effect, Botox is very commonly used in cosmetic surgery. At present, the dosage is only 1% of its maximum safe dosage, so it is very safe, and Botox has a good face-lifting effect. Generally, 1 ~ 2 injection points are selected for injection on each side, and the injection process takes about 20 minutes, so there is no need for anesthesia, and the injection wound is small and the recovery is fast. 2-3 weeks after injection, the masseter muscle began to contract, and the face-lifting effect appeared. The face-lifting effect of Botox can last for about a year, and then gradually recover. After several injections, the muscles gradually atrophy before they can be shaped. Chewing and biting should be avoided after plastic surgery with Botox. Answer: Leg length: greater than 26.3% of height.

B: Maximum girth: about 3/4 of the length of the calf.

Leg size:

C: Last week's length is equal to the maximum circumference (B)

D: The middle circumference is the upper circumference plus the lower circumference (B+C) divided by 2.

E: The length of next week is 63% of that of last week.

Botox 1 and Botox A have the best effect on facial wrinkles 1/3. Such as forehead lines, brow lines, crow's feet lines and wrinkles on the back of nose, are suitable for people who are unwilling to have surgery, people who are worried about surgery, people who are not suitable for cooperating with surgery, and people who still have fine lines after face wrinkle removal.

2, eyebrow shaping: the correction of eyebrow asymmetry, smoothing the mouth and shaping the mouth;

3, face-lifting, stovepipe: For those with facial masseter hypertrophy and well-developed calf muscles, you can achieve the effect of face-lifting and stovepipe.

4. Face wrinkle removal age: The age suitable for wrinkle removal surgery is 33-60 years old. The suitable age reported abroad is 35 ~ 75 years old. Surgery can't stop the development of aging, but it can treat and prevent signs of aging. With the change of subjective and objective needs, the number of people aged 30 ~ 40 who require rhytidectomy has increased, but it should only be listed as a relative indication of small-scale local surgery.

5. Aging condition of face and neck: The changes of aging include drooping and wrinkles mentioned above, which are different in position, nature and degree. Generally speaking, wrinkle removal surgery is effective and reliable for people with drooping cheeks and jaws; The effect of gravity rhytidectomy is lasting; It has a good effect on dynamic wrinkles such as forehead lines, vertical lines between eyebrows and horizontal lines at the root of nose.

Wrinkle removal technology is still not ideal for the treatment of nasolabial groove, but it is ineffective for the longitudinal lines of upper and lower lips. The traditional face-lifting wrinkle only tightens the skin, and the effect can only last for 2 ~ 5 years.

Wrinkle removal technology corrects many tissues related to aging changes, such as fat, muscle and other deep tissues of the face and neck, and tightens the skin. For many people, the effect of surgery is lasting, and the relaxation of fat and muscle is limited, but the skin will relapse and relax over time. How long can modern wrinkle removal technology last? It is generally considered to be 5 ~ 10 years at home and abroad.

6, physical condition: unintentional, brain, liver, lung, kidney disease and other important organs; Scarless constitution; No skin diseases and blood system diseases; Hypertension has been effectively controlled by drug treatment. The emaciation period is better than the obesity period, and the long face is better than the wide face.

Contraindications

1, myasthenia gravis

2. People with neuromuscular diseases

3, allergic constitution

4. Pregnancy and lactation

5. Those who have a history of drinking alcohol within one week (including beer)

6. Take aspirin or other antipyretic and analgesic drugs orally within two weeks.

7. Those who use aminoglycoside antibiotics (such as gentamicin and streptomycin).

8, psychological barriers, poor self-control ability.

9. Patients with multiple sclerosis

10, patients with ptosis

1 1, adrenaline patients and patients with heart, liver, kidney and other visceral diseases cannot use it.

12. People (such as actors, etc. People who can't reduce the frequent activity of facial expression muscles have no side effects by injecting botulinum toxin within a safe range, but if they are injected too much or have problems with the injection method, or used together with other antibiotics, side effects may occur. The main manifestations are: hitting the face too much may cause swallowing difficulties; The face will become stiff and the smile will be unnatural; There is local swelling and fever. Generally speaking, these clinical manifestations are short-lived and disappear naturally within a few weeks.

Botulinum toxin injection still has some complications and side effects:

1, if local headache is caused by injection;

2. If the head tattoo is injected incorrectly, ptosis will occur;

3. Improper crow's feet injection will lead to diplopia and incomplete eye closure;

4. Because the injection dose is not accurate, there will be asymmetric results on more than one side and less than one side;

5. There are occasional bleeding or hematoma when acupuncture breaks blood vessels;

6. Large doses and repeated injections may cause immune complex diseases;

7. As a result of muscle paralysis, it is impossible to make various expressions, and people's facial expressions will be partially lost, making people feel like masks;

8. Very few patients may have anaphylactic shock.

A week after the initial treatment, the patient should be reexamined, and the treatment effect and complications at this time will be very accurate. A few patients may need supplementary injections to determine the ideal dose for each patient. There are also some precautions, such as patients should stop using aspirin and aspirin drugs before injection 14 days; Stop using cosmetics on the day of injection; Do not massage the local area after injection to avoid the spread of toxins.