These factors play an extremely important role in promoting wound healing, cell proliferation and differentiation and tissue formation. Previously, PRP was mainly used in surgery, cardiac surgery and burn department to cure large-scale burns, chronic ulcers and limb ulcers that could not be cured before.
PRF live fat filling technology is autologous fat filling. Autologous fat filling surgery is to extract excess fat from the waist, abdomen, thighs and other parts of the patient, and then purify the fat. After the center of the circle is separated by a centrifuge, pure fat particles are extracted and filled in the parts needed by the operator.
Platelet-rich plasma (PRP) is a platelet concentrate obtained by centrifuging autologous whole blood. No adipose-derived stem cells, high platelet content. Because platelets contain a variety of active cytokines, they can promote the growth and survival of autologous fat cells.
Platelet-rich plasma is produced only by blood centrifugation without adding too many bioactive proteins (such as enzymes), which is safer than ADSCs and SVF, and has the characteristics of short processing time, short preparation time and more convenience.
Compared with PRP, platelet-rich fibrin (PRF) is a scaffold containing more fibrin, and its preparation process is similar to PRP, but its effect is better and its safety is stronger.
Extended data
"PRP autologous living cell rejuvenation" and "PRP autologous cell rejuvenation" Some hospitals package PRP as the key to determine the survival rate of fat and the role of fat filling:
The 6-month survival rate of filled adipose tissue is only 30%~70%, so it is necessary to ensure the amount of filled adipose tissue by multiple injections. However, it was found that the main problems affecting the absorption were that mature adipocytes could not regenerate, and their tolerance to hypoxia was low, while the establishment of microvessels in the recipient area was very slow, which could not meet the blood supply of transplanted fat, leading to the absorption of adipose tissue.
The key to solve the survival rate of fat filling lies in the regeneration of fat cells and the establishment of blood supply in the recipient area.
PRP(PlateletRichPlasma) is a small amount of platelet-rich plasma. 1993, AGHood and others first put forward the concept of platelet-rich plasma. In 1998, Marx et al. used PRP extracted from centrifugal whole blood as the source of growth factor for tissue repair for the first time. In recent years, PRP has been widely used in orthopedics, burns, plastic surgery and dermatology.
Platelet-rich plasma (PRP) contains many growth factors, such as VEGF, PDGF, EGF, TGF B and so on. Among them, VEGF can promote the proliferation of adipose-derived stem cells and differentiate into vascular endothelial cells, which plays a certain role in tissue growth and repair.
These growth factors will be beneficial to the oxygen and blood supply of transplanted adipose tissue in the recipient area, thus improving the survival rate and renewal of adipose cells and reducing the absorption rate. However, the total amount of growth factors released and the amount of growth factors contained have not been studied yet.
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