Question 1: How to donate bone marrow? First, you register at the branch of China Marrow Bank where you are located. They will interview you to let you understand the entire process of donating hematopoietic stem cells and ask you again about your attitude towards donating and collecting hematopoietic stem cells.

Before you donate, you will be asked to undergo a comprehensive physical examination to confirm that your health meets the conditions for donation.

A "Consent Form for Donating Hematopoietic Stem Cells" needs to be formally signed. In the 2 to 4 weeks before donation, you will be asked to maintain a healthy state and go out as little as possible to reduce the occurrence of colds and other adverse health conditions.

Finally, 2 to 3 days before the actual collection and donation, you will be asked to eat less greasy food, sleep well, and not be nervous, etc., to maintain a good mood and condition.

Then, another 5 ml blood sample needs to be taken for high-resolution typing testing to confirm that it matches the patient's type.

Registration as a volunteer and actual collection and donation are all based on voluntariness, so we will make an appointment with you for an interview to reconfirm your voluntary nature. Because high-resolution HLA testing requires a lot of money, if you change your decision, you don’t need to do expensive testing to increase the burden on the patient. On the other hand, if you do a high-resolution test and sign the "Consent Form for Donating Hematopoietic Stem Cells", the patient will also be prepared for transplantation and undergo high-dose radiotherapy or chemotherapy, causing the patient to lose his hematopoietic ability. If you change your original intention at this time, the patient will not only lose hope of survival, but will also hasten his or her death. This is an undesirable consequence. Therefore, we hope you will think carefully when signing up to donate.

There are two main ways to collect hematopoietic stem cells:

One is to extract hematopoietic stem cells from bone marrow. The donor needs to be under general anesthesia or local anesthesia, and bone marrow blood is extracted from the donor's ilium;

The second is to collect hematopoietic stem cells from peripheral blood. That is, the donor is injected with a hematopoietic stem cell mobilizing agent to mobilize a large number of hematopoietic stem cells in the bone marrow into the peripheral blood. A needle is inserted from the donor's elbow vein, and through the action of a "blood cell separator", the hematopoietic stem cells in the peripheral blood are removed. Hematopoietic stem cells are collected in 50 ml plasma bags, and other blood components are returned to the donor.

In my country, peripheral blood is currently used to collect hematopoietic stem cells.

Under normal physiological conditions, the amount of hematopoietic stem cells in peripheral blood is very small and cannot meet the needs of transplantation. After the drug is mobilized, it accelerates the generation of bone marrow hematopoietic stem cells and releases them into the peripheral blood, which can increase the number of peripheral blood hematopoietic stem cells by 20 to 30 times, so that hematopoietic stem cells that can meet the needs of transplantation can be collected from the peripheral blood.

The full name of the mobilizing agent is "Granulophage-macrophage colony-stimulating factor (GM-CSF)". In addition to increasing the number of hematopoietic stem cells in peripheral blood, it also has functions such as assisting cardiac function. There are no reports or conclusions that it is harmful to human body.

First of all, we solemnly state that we will never rescue patients at the expense of the health of donors. Because hematopoietic stem cells in the human body have strong regenerative capabilities, under normal circumstances, various cells in the human body are constantly metabolizing every day and undergoing cycles of generation, aging, and death. After blood loss or donation of hematopoietic stem cells, they can be regenerated. The bone marrow accelerates hematopoiesis, and within 1 to 2 weeks, various blood cells in the blood return to their original levels. Therefore, donating hematopoietic stem cells will not affect your health.

Sanskrit says: Saving a life is better than building a seven-level pagoda. It means that saving people's lives is a good deed with infinite merit.

In the process of helping others, you will naturally feel a sense of joy in your heart. At the same time, a person who firmly believes that living in the world is beneficial to others and beneficial to society will eliminate his inferiority complex and enhance his self-confidence in life. Giving charity can bring about a balanced mental state, and a balanced mental state is the basis for preventing many diseases. Scientists have also found that the thoughts and actions of helping others and being kind to others are beneficial to the establishment and improvement of the function of the human immune system. The effect of emotions on the immune system is obvious. Healthy emotions communicate with the brain and other tissues and organs through the nervous, body fluid, and endocrine systems, keeping them in a state of benign dynamic balance, allowing people to enhance their ability to resist infection, and thus protect themselves from various diseases. Therefore, doing good deeds and doing good deeds not only helps others, but also helps yourself.

There is a blood donation poster with the slogan "It is more blessed to give than to receive", which means exactly this.

Marrow donors use their love to extend and save the lives of others, which embodies the noble sentiments of human beings living together, cherishing life, and being friendly and helping each other. Love comforts the soul and makes life more fulfilling and happy. Always maintaining a fulfilling and happy mood is one of the essential factors for health and longevity.

Finally...>>

Question 2: How is bone marrow extracted when donating? My friend, I have introduced it to you in detail, 1. Bone marrow is the body's hematopoietic tissue and is located in many bones of the body. There are two types of bone marrow in adults: red bone marrow and yellow bone marrow. Red bone marrow can produce red blood cells, platelets and various white blood cells. Platelets have a hemostatic effect; white blood cells can kill and inhibit various pathogens, including bacteria and viruses; some lymphocytes can produce antibodies. Therefore, bone marrow is not only a blood-producing organ, it is also an important immune organ. Yellow bone marrow is mainly adipose tissue, which can be converted into red bone marrow when the body is anemic. 2． Will donating bone marrow affect the donor's health? Donating bone marrow will not affect a person's health. Many people think that donating bone marrow means extracting spinal cord. This is completely a misunderstanding. Bone marrow transplantation requires red bone marrow - hematopoietic stem cells - from the human body. The amount of hematopoietic stem cells in an adult is 3 kilograms. A donor can save a leukemia patient with less than 10 grams of bone marrow stem cells without compromising his immunity and hematopoietic ability. Bone marrow is a tissue with a strong reproductive capacity. For healthy donors, the amount of donated stem cells can be replenished in about 10 days. 3. At what age is a healthy person suitable for donating bone marrow? Healthy people between the ages of 18 and 55 can donate bone marrow. 4． What is bone marrow transplant? Bone marrow transplantation refers to the transplantation of hematopoietic stem cells in the bone marrow from one person to another (usually through intravenous infusion). To be precise, bone marrow transplantation is the transplantation of hematopoietic stem cells. 5. Who needs a bone marrow transplant? Serious diseases of the human blood system and immune system, such as leukemia (commonly known as blood cancer). For patients with lymphoma, aplastic anemia thalassemia, and seriously ill radiation sickness, the hope for continued survival is bone marrow transplantation. About 4 million patients with various diseases in my country are waiting for bone marrow transplants every year. In addition to the donor's weight, blood pressure and other physical health conditions being the same as those for blood donation, bone marrow donors are generally required to be over 18 years old and under 45 years old. It is best to have experience in donating blood or platelets. Once sampled, the matching requirements are also required For those who are physically and mentally mature, it is easier to treat patients. Strictly speaking, marrow donation is actually donating hematopoietic stem cells. The one-time donation amount is about 20 grams, which has no impact on the body. Citizens can donate blood voluntarily. Fill out a voluntary marrow donation form, so that after the hospital enters the relevant information into the information database, it can invite volunteers to save lives and heal the wounded at any time. How to donate bone marrow 1. How to become a voluntary donor? If you are between 18 and 55 years old and in good health, you can call the bone marrow donation hotline of China Marrow Bank: (Beijing) 010-65126600, (Shanghai) 021-62478117, or register at the Red Cross Society at or above the district or county level, and Fill out the volunteer donation form and related forms. 2. What are the steps for donating bone marrow? 1) After registration, the bone marrow bank or the Red Cross will arrange for you to take a 5 ml blood test, and store the HLA typing results in the Chinese Hematopoietic Stem Cell Donor Database for patients to find matches. 2) The initial matching between the donor and the recipient is the same. The staff of the bone marrow bank will introduce you to the donation process in detail and ask you to undergo a full body examination. 3. How to extract bone marrow? There are two ways to extract hematopoietic stem cells from bone marrow: First, the doctor punctures the donor's iliac bone to collect hematopoietic stem cells in the bone marrow. There will be some pain for one or two days after the operation, but full recovery can be achieved within a week. The second is to use scientific methods to effectively mobilize hematopoietic stem cells from the bone marrow and other parts of the body and release them into the peripheral blood in large quantities. They are collected from the donor's arm veins, and the hematopoietic stem cells are separated through a machine, and the remaining blood is returned to the donor. in vivo. 4. Will donating bone marrow affect your health? Many people think that donating bone marrow means extracting spinal cord. This is completely a misunderstanding. Bone marrow transplantation requires red bone marrow - hematopoietic stem cells - from the human body. The weight of an adult's bone marrow is 3 kilograms. A bone marrow donor can save the life of a leukemia patient by providing less than 10 grams of bone marrow hematopoietic stem cells. Bone marrow is a tissue with strong regenerative ability. Generally, healthy people can replenish the amount of donated stem cells in about ten days after donating hematopoietic stem cells. Therefore, donating bone marrow will not affect a person’s health.

Question 3: What are the steps to donate bone marrow? The following is reproduced from the Hematopoietic Stem Cell Charity Forum.

The process of hematopoietic stem cell donation

1. When a patient matches your type and needs your donation, the China Hematopoietic Stem Cell Donor Database Management Center will use the branch’s comrades to Once again, your wishes are sought. If you are willing to donate, you will need to do a high-resolution blood test to confirm that the match is correct.

2. After the high-resolution photoshoot, a comprehensive physical examination will be conducted for the safety of both parties.

Physical examination items:

Internal medicine system: blood pressure, skin examination, lymph node examination, cardiopulmonary auscultation, thyroid

Auxiliary examination: chest X-ray, electrocardiogram, abdominal B-ultrasound

Blood tests: blood routine, blood type, hepatitis B two and a half, hepatitis A, hepatitis C antibodies, cytomegalovirus antibodies (IgG, IgM), blood sugar, kidney function, liver function, HIV antibodies (enzyme labeling method) , Treponema pallidum antibodies

3. After all tests are passed, the transplant time will be determined and the mobilization agent will be injected

You will be admitted to the collection hospital 4-5 days before the transplant and receive one injection every day Cell colony *** factor is mainly used to fully mobilize the hematopoietic stem cells in your body (mobilizing agent: promotes the large-scale growth and release of hematopoietic stem cells into the peripheral blood).

4. Collect hematopoietic stem cells

On the day when the patient is confirmed for transplant, start collecting your hematopoietic stem cells.

Collection method: Drain the blood from your arm vein into the blood separator, enrich the hematopoietic stem cells, and infuse all the remaining blood components back to you. The whole process takes 3-4 hours. , and then you can take a short break.

The time of collection should be judged based on the weight of the patient and donor.

Generally, it is determined based on the patient's weight whether you want to collect once or twice. If the patient is a child, sometimes one time can meet the patient's needs. Generally speaking, 100-150ml of hematopoietic stem cell suspension can save a patient. After collection, it must be injected into the patient within 24 hours.

5. Follow up regularly and purchase health insurance for the donor for one year.

Long-term follow-up is carried out on each donor to protect the health of the donor and establish our own clinical data on the donor. Blood tests will be arranged 10 days, 1 month, 3 months, and 6 months after the donor donates hematopoietic stem cells, and a comprehensive physical examination will be arranged after 1 year, 3 years, and 5 years.

The insurance is provided by Ping An Insurance Company of China and is worth 300,000. (The period is one year)

Question 4: What are the requirements for donating bone marrow? Instructions for donors 1. What are the health standards for voluntary hematopoietic stem cell donors? Anyone aged 18-55 who is in good health and passes the following blood tests can become a hematopoietic stem cell donor. Alanine aminotransferase (ALT) ≤ 40 units Hepatitis B virus surface antigen: negative Hepatitis C virus antibody: negative HIV antibody: negative Syphilis test: negative 2. At what age is a healthy person suitable to donate hematopoietic stem cells? Healthy people aged 18-45 who meet the conditions for unpaid blood donation can register as volunteers to donate hematopoietic stem cells, and healthy people aged 18-55 can collect hematopoietic stem cells. 3. Why are healthy people aged 45-55 no longer accepted for registration? The optimal age for collecting hematopoietic stem cells is 18-55 years old. It takes a certain amount of time to find a suitable patient after the donor is registered in the database. In order to make full use of limited testing funds, the registration age is preferably no more than 45 years old. 4. How to join the Chinese Hematopoietic Stem Cell Donor Database and become a volunteer to donate hematopoietic stem cells? If you are of appropriate age, in good health (meeting the conditions for voluntary blood donation), and wish to donate hematopoietic stem cells, you can contact the hotline of the local Red Cross (or Chinese Marrow Bank branch) to sign up, fill in the voluntary donation form and related forms, and draw 6~ 8 ml of blood. The tissue matching laboratory will conduct HLA typing and other tests on your blood, and enter all your relevant information into the computer database of the China Hematopoietic Stem Cell Donor Database. You then become a volunteer to donate blood stem cells. 5. How do you know that you have become a hematopoietic stem cell donation volunteer? The China Hematopoietic Stem Cell Donor Database has branches across the country. You will be notified of your acceptance as a hematopoietic stem cell donor and will be kept in touch with you regularly. 6. Are there any subsidies for donation registration and hematopoietic stem cell donation? Donating hematopoietic stem cells is a dedication of love and a life-saving act of charity. Subsidies are generally not advocated. 7. After registering as a volunteer, do you need to donate hematopoietic stem cells immediately? After registering as a volunteer, you will first be asked to draw 6 to 8 ml of blood for HLA typing testing, and the data will be stored in the China Hematopoietic Stem Cell Donor Database for future reference. When a patient needs a hematopoietic stem cell transplant, the transplant center will transmit the patient's HLA typing data to the database. If the search results reveal that your HLA matches the patient's, the provincial management center will notify you to donate. preparation. This process may be short or may take several years. Most volunteers may not have the opportunity to donate. 8. What issues should you pay attention to as a volunteer donating hematopoietic stem cells? When you or your contact's phone number or address changes, we hope to notify the registration department in time so that patients can find you quickly when needed, so that the patient's disease can be treated in a timely manner, and to ensure that you realize your desire to save lives. 9. Can I change my decision to donate hematopoietic stem cells at any time after signing up? Registration and donation are based on voluntariness. After registration, the database will reconfirm your voluntariness. During this period, you can request to terminate your donation.

However, because testing your blood sample for HLA has already consumed the limited funds of the bone marrow bank, in order to make good use of precious social donations, if you propose to terminate donation, please consider it carefully. However, before the transplant, especially after signing the donation consent form, you cannot change the decision to donate, because at this time, the patient has undergone high-dose radiotherapy and chemotherapy in preparation for the transplant, and has lost his hematopoietic ability. If you terminate the donation during this period, you will need to find another temporary It's too late for a matching match, and the patient's life will be in danger. 10. Why do donors need to fill in the consent form and donor registration form? Joining the China Hematopoietic Stem Cell Donor Database and becoming a volunteer to donate hematopoietic stem cells is a noble act of dedication. When needed, the donor will donate hematopoietic stem cells to patients free of charge. Therefore, the China Hematopoietic Stem Cell Donor Database must be obtained The donor’s written commitment, and the donor’s accurate mailing address and contact information are known through the registration form. 11. When a donor fills out the registration form, why does he need to fill in the names and contact information of two relatives or friends of the donor with different addresses? When the donor cannot be contacted for a while, the donor can be contacted in time through other channels to avoid loss. 12. After a donor registers in the "China Hematopoietic Stem Cell Donor Database", what method is used to perform HLA typing on the donor, and what items are required? The China Hematopoietic Stem Cell Donor Database stipulates that tissue matching laboratories located in various places will use molecular biology techniques to conduct HLA typing on each donor's blood sample, and at least the HLA must be correctly identified... >>

Question 5: How to donate bone marrow 1) Those who are 18-45 years old, in good health, and volunteer to donate bone marrow are terrible

Call the local Red Cross to sign up; < /p>

(2) Arrange for you to do a blood test (5 ml) at an appropriate time, and store the HLA types after the test in a computer database for patients to find matches; < /p>

(3) After the initial matching is the same, the bone marrow bank will notify you for further blood testing;

(4) If the matching is exactly the same, the staff will introduce it to you in detail Donation process, and

arrange for a full body check-up. Those who qualify will be donated;

(5) When donating, you are completely awake and blood stem cells are collected from your arm veins (total volume is 50 ml) , collected through a blood cell separator, and the remaining blood

returned to the body.

Question 6: What are the requirements for bone marrow donation? You can go to the local blood station or the Red Cross for consultation~~~ The physical requirements are as follows: (Although it is reprinted, I hope it will be useful to you. Helpful) What are the health standards for voluntary hematopoietic stem cell donors? Anyone aged 18-55 who is in good health and passes the following blood tests can become a hematopoietic stem cell donor.

Alanine aminotransferase (ALT) ≤ 25 units (the hospital uses ≤ 40 units) Hepatitis B virus surface antigen: negative Hepatitis C virus antibody: negative HIV antibody: negative Syphilis test: negative The following are the health of volunteer donors Status consultation form Height: cm Weight: kg (weight requirement: male >= 50 kg, female >= 45 kg) 1. Are you between 18~45 years old? Yes ( ) No ( ) 2. Are you in good health? Yes ( ) No ( ) 3. Do you understand the entire process of hematopoietic stem cell donation? Yes ( ) No ( ) If you meet the above conditions, please continue to answer the following questions (if any of the above 18 items is "yes", you cannot be registered in the database): 1. Have you ever suffered from hepatitis B or C, and are you currently suffering from hepatitis B? Hepatitis surface antigen or hepatitis C antibody positive? 2. Have you ever suffered from allergic diseases with recurring attacks, such as urticaria, bronchial asthma, drug allergies, etc.? 3. Have you ever suffered from tuberculosis, such as pulmonary tuberculosis, renal tuberculosis, lymph node tuberculosis and bone tuberculosis? 4. Do you suffer from cardiovascular diseases, such as various heart diseases, hypertension, hypotension, myocarditis, thrombophlebitis, etc.? 5. Do you suffer from respiratory diseases, such as chronic bronchitis, emphysema, bronchiectasis, and pulmonary insufficiency? 6. Do you suffer from digestive system or urinary system diseases, such as severe gastric and duodenal ulcers, chronic gastroenteritis, acute and chronic nephritis, chronic urinary tract infection, nephrotic syndrome and chronic pancreatitis? 7. Do you suffer from blood diseases, such as anemia, leukemia, polycythemia vera and various bleeding and coagulation diseases? 8. Do you suffer from endocrine diseases or metabolic disorders, such as pituitary gland disease, adrenal gland disease, hyperthyroidism, acromegaly, diabetes insipidus and diabetes? 9. Do you suffer from organic neurological diseases or mental illness, such as encephalitis, sequelae of traumatic brain injury, epilepsy, schizophrenia, hysteria, and severe neurasthenia? 10. Do you suffer from benign tumors that affect your health? 11. Have you ever had any surgery to remove important internal organs such as the stomach, kidneys, spleen, etc.? 12. Do you suffer from chronic skin diseases, especially infectious, allergic and inflammatory systemic skin diseases, such as generalized eczema and systemic psoriasis? 13. Do you suffer from high myopia with fundus lesions? 14. Do you suffer from autoimmune diseases and collagen diseases, such as systemic lupus erythematosus, dermatomyositis, scleroderma, etc.? 15. Are you suffering from sexually transmitted diseases, syphilis, leprosy, AIDS or HIV infection? 16. Do you have a history of drug abuse? 17. Have you ever been refused free blood donation because you have other diseases that prevent you from donating blood? 18. Have you ever had whole blood or blood components transfused within the past five years? Below is a detailed explanation of the above items: What are the health standards for voluntary hematopoietic stem cell donors? Anyone aged 18-55 years old, in good health, and has passed the following blood tests can become a hematopoietic stem cell donor. (The age range mentioned here is the age for donation, and 18-45 is the age for donation registration. There is no conflict between the two) The following is the health status consultation form for volunteer donors Height: cm Weight: kg (Weight requirement: Male >= 50 kg, female >= 45 kg) Weight requirements: A person’s blood is directly proportional to his body weight, accounting for about 7-8%. Donating hematopoietic stem cells is also a type of blood donation, so with reference to the blood donation standards, a Weight requirements. 1． Are you between 18~45 years old? Yes ( ) No ( ) The age limit on whether those under 18 years old can donate may be based on two reasons. One is because those under 18 years old do not have full civil rights and therefore cannot legally complete donations independently; Another reason is that due to physical reasons, the bodies of those under 18 are not yet mature, and most of them do not reach the weight limit for donation. There are also donations made by those under 18 years old, but these are all related donations and are a last resort measure. Therefore, this cannot be done with non-blood related donations. Description of the upper age limit: The maximum age for registration is 45 years old, but the donation age is: 18 to 55 years old. Because the match was successful... >>

Question 7: What are the disadvantages of donating bone marrow? How noble it is to donate your own bone marrow to patients and save those brothers and sisters who are dying. action! With the development of bone marrow transplantation, more and more people are responding to bone marrow donation. However, there are also many people who do not understand the process of marrow donation and lack this knowledge, and they cannot help but worry about whether marrow donation will affect their health. In fact, this kind of worry is unnecessary. Many types of blood cells in our body come from the same ancestor - multipotent hematopoietic stem cells. Not only can it continue to differentiate into descendants, but it can also replicate cells that are exactly the same as itself. This allows our hematopoietic function to continue continuously. When old blood cells die, new ones grow to replace them; when some hematopoietic stem cells are damaged, healthy stem cells are quickly born to compensate. Our bodies work so well together. Pluripotent stem cells are not numerous and are distributed throughout the bone marrow. When donating bone marrow, only a small part of the body's bone marrow is extracted, and only part of the pluripotent stem cells are lost. The remaining pluripotent stem cells will replicate quickly, and the hematopoietic function will completely return to normal in a short period of time. Therefore, donating bone marrow will not affect a person’s hematopoietic function.

Some people are also afraid of the operation of donating bone marrow. Here is an introduction to the operation of collecting bone marrow: After the marrow donor is deemed qualified after a comprehensive physical examination, the operation will be performed under continuous epidural anesthesia or general anesthesia (the anesthesia method is the same as that of a general operation), and the bone marrow collection will be performed. The parts mostly use the ilium, commonly known as the hip bone, and the sternum is also used. The method of marrow collection is similar to the usual bone marrow puncture examination. A needle is inserted to aspirate a few milliliters of bone marrow fluid. The amount of bone marrow collected is based on the patient's weight and the number of cells in the donor's bone marrow fluid. The number of transplanted bone marrow cells cannot be less than 3.0×108 kg of patient weight. If it is too small, the transplantation will not be successful. Therefore, adults generally need to donate about 800-1000 ml of bone marrow. In fact, so much bone marrow fluid is mixed with a large amount of blood, so appropriate blood transfusions are required during the operation. When the number of cells reaches the required number, the surgery is over. After surgery, you will feel pain in the surgical area due to the large number of puncture points, which usually disappears within two weeks. Many marrow donors can return to work 3-4 days after surgery, and the youngest marrow donor is nearly 2.5 months old. These indicate that donating bone marrow is safe for healthy people. Dear reader, after reading the above answers, you are probably no longer very worried, right? When your friends or relatives are in need, you will definitely lend a helping hand, right?

Please accept

Question 8: Donate bone marrow Hello, first of all, I would like to express my sympathy for your misfortune. I would like to give you a big thumbs up for your charity. The donation process is as follows: 1. Leave a sample and add it to the Chinese Marrow Bank (leave a 6-8 ml blood sample in the blood truck or blood station and fill in the registration form) 2. If the patient retrieves your and his bone marrow type (HLA typing information ) If you approach the bone marrow bank, you will be contacted to ask if you are willing to donate. 3. If you agree to donate, you will undergo a physical examination and collection. 4. The collection is peripheral blood collection, just like blood donation. It does no harm to the body. There are two pains. One is injection mobilization. I had cold symptoms when I took the medicine. Secondly, I couldn’t move in bed for about 3 hours at most twice during the collection, and I felt uncomfortable such as numbness in my body. You can go home after collecting. There are no other effects.

Question 9: I want to donate bone marrow. How do I donate bone marrow? Donating bone marrow is not a direct donation. You have to register when you donate blood. If you fill in the form that you are willing to donate bone marrow, your data will be recorded and used when needed. I will notify you~