Nucleotide filling is a common facial plastic surgery method. Nucleotide is injected into skin tissue by injection to achieve the effect of filling, smoothing wrinkles and improving facial contour. Compared with other fillers, nucleotide fillers have better biocompatibility and durability. However, once nucleotide fillers are injected into skin tissues, they usually cannot be dissolved or decomposed. This means that if you are not satisfied with the effect of nucleotide filling, or have adverse reactions, you usually need to repair or remove it by other methods or surgery. Common repair methods include the use of reverse filling or surgical resection.