Ozone treatment of lumbar disc herniation is a new treatment method in recent two years. Ozone is a strong oxidant. It can destroy proteoglycan in nucleus pulposus matrix, lead to dehydration and atrophy of nucleus pulposus, and relieve the compression of prominent nucleus pulposus on nerve roots. At the same time, ozone can also destroy nucleus pulposus cells and reduce the production and secretion of proteoglycan in nucleus pulposus. In addition, the experiment also confirmed that ozone can promote the dissipation of inflammatory process, mainly through the following aspects: affecting the release of cytokine antagonists such as IL 10, TGFβ 1 and/or autoimmune suppression; Cause the over-expression of antioxidant enzymes to neutralize excessive reaction products; Stimulating the production of vascular endothelial cells with PDGF will not cause vasodilation, which will lead to the disappearance of inflammation. For the solution of postoperative infection, ozone itself has disinfection effect, which greatly reduces the chance of infection. However, the application scope of ozone therapy is narrow, with an injection of less than 20ml, which is only effective for mild disc herniation, but ineffective for moderate and severe disc herniation, and cannot directly eliminate the nucleus pulposus tissue that compresses nerves. The effect of one treatment is not good, and it often takes 2-5 treatments to get satisfactory results. In addition, due to the increased pressure in the intervertebral disc after ozone injection, patients may have aggravated symptoms. Ozone has a good effect on relieving the symptoms of disc herniation, but it has no effect on treating disc herniation.