According to academic research, the onset of acne is hyperkeratosis in the funnel of hair follicle and sebaceous gland duct; The stimulation of microbial decomposition of sebum to produce free fatty acids causes inflammation and tissue destruction; Cellular immunity and humoral immunity mediated by Corynebacterium acne participate in local inflammatory reaction. Antibacterial, anti-inflammatory and sebaceous gland inhibition are often used in clinic, but the effect is little and acne remains. In fact, small acne hides big problems, and endocrine disorders are the key to recurrent acne.