First, pregnancy factors
This factor is the most common one, which is related to the increased stimulation levels of progesterone, estrogen and pituitary melanocytes in the body. Therefore, it is particularly common in pregnant women, generally occurring in 2-5 months of pregnancy, and gradually disappearing with the recovery of menstruation after delivery. But quite a few people persisted.
Second, the drug factor.
Women who take oral contraceptives often appear after taking 1-20 months. Estrogen can stimulate melanocytes to secrete melanosome, and progesterone can promote the transport and diffusion of melanosome.
Third, endocrine factors.
Female reproductive system diseases such as menstrual disorder, dysmenorrhea, adnexitis and infertility; Patients with chronic systemic diseases, such as chronic alcoholism and chronic liver disease. There is often chloasma.
Fourth, cosmetic factors.
Poor quality or improper use of cosmetics can lead to melanosis. The perfume, decolorant and preservative contained in cosmetics have direct stimulation or sensitization to the skin, which will cause local inflammation and pigmentation of the skin; The content of lead, mercury, copper and other heavy metals in cosmetics exceeds the standard, which can enhance tyrosinase activity after being absorbed by skin, thus accelerating pigment synthesis.
Verb (abbreviation for verb) nutritional factors
Lack of vitamins A, C, E, nicotinic acid or amino acids in food is also a common cause of chloasma.
Six, sun exposure factors
Heredity, ultraviolet radiation and skin microecological imbalance are also closely related to chloasma. The data show that 30% patients with chloasma have family history; Solar ultraviolet irradiation can improve the activity of melanocytes and promote the production of chloasma.