Goat endemic intranasal tumor is a chronic, progressive and contact infectious disease caused by ENTV-2 prevalent in this area. The clinical manifestations are dyspnea, runny nose and unilateral or bilateral nasal cavity growth. Although the incidence rate is not high, the mortality rate is 100%, and most of them are adult sheep, which has caused great economic losses to farmers. In recent years, the disease has been reported in Inner Mongolia, Hunan, Sichuan, Shaanxi and other places in China, which has gradually attracted the attention of sheep industry.