In computer, negative numbers are represented by complement, that is, negative code plus 1 positive number is directly represented by original code. Because-1 is a negative number, 00000000001111111. +00+ 1 means1111111.

Positive numbers less than 32768 remain unchanged. When they are negative, the sum of their absolute values is 65536 (16 to the second power). You also explained that integers in your compiler are represented by two bytes. In the binary of -2, it is1111165438.

Wnt signal and organogenesis;

Wnt signal is involved in brain formation. Wnt 3a gene knocked out mouse embryos, and the development of hippocampus was damaged. Lef？ Homozygous mutation can lead to the loss of all hippocampus in mouse embryos; Wnt/ LEF/TCF genes cooperate, and * * * participates in the development of hippocampus.

Wnt signal is involved in the reconstruction of growth cone and the formation of polysynaptic spherical ring (when moss nerve fibers contact granular cells). Participate in the initial process of axon formation: Wnt7a can induce the reconstruction of axons and growth cones in mossy nerve fibers and the aggregation of hapten ⅰ.

Wnt signal is involved in the initiation of vertebrate limbs and the formation of apical ectodermal ridge. Three Wnt signaling molecules (Wnt2b, Wnt3a, Wnt8c) are the key inducers of signal transduction. The information exchange between FGF and Wnt signals is also related to the formation of inner ear. ?