Does it hurt to make up with hyaluronic acid? Actually, it has a lot to do with the doctor's skill. I used to hit my nose with hyaluronic acid in Fuai Medical, and it didn't hurt for a long time. Generally speaking, I will use an anesthetic. Usually this kind of painful stimulation is completely tolerable. Because it is only a needle, and it is deeply filled, it generally does not affect the obvious pain, so it should be tolerable.