Non-invasive DNA detection, that is, non-invasive DNA prenatal detection technology, refers to taking pregnant women's venous blood, sequencing the free DNA fragments (including fetal free DNA) in pregnant women's peripheral plasma by using a new generation of DNA sequencing technology, and analyzing the biological information of the sequencing results, so as to obtain the genetic information of the fetus, so as to detect whether the fetus has three chromosome diseases.
Extended data:
dna sequencing
The most widely used is Sanger dideoxy chain termination method, a DNA sequencing technology invented by frederick sanger. In molecular biology research, DNA sequence analysis is the basis for further research and transformation of target genes.
Dideoxy chain termination method (1977) invented by Sanger et al. and chemical degradation method (1977) invented by maxam and Gilbert.
These two methods are quite different in principle, but they are both based on the fact that nucleotides start at a fixed point and randomly end at a specific base, resulting in a series of four groups of nucleotides with different lengths, which are then detected by electrophoresis on urea denatured PAGE gel, thus obtaining the DNA sequence.
References:
Baidu Encyclopedia-Noninvasive DNA Prenatal Detection Technology
References:
Baidu encyclopedia -DNA sequencing method