Served as Director of the Personnel Department, Vice President and Party Committee Member of Qianfoshan Hospital of Shandong Province, and Assistant to the District Governor of Yubei District, Chongqing City.

In September 2006, he was appointed as the president and deputy secretary of the party committee of Qianfoshan Hospital of Shandong Province.

In January 2010, he was appointed as the deputy director and member of the party committee of the Shandong Provincial Department of Health.

On January 12, 2011, the Shandong Provincial People's Government decided to remove Xi Yan from the position of president of Qianfoshan Hospital of Shandong Province.

On November 2, 2011, he was elected president of the third council of Shandong Preventive Medicine Association.

2012.1 Deputy Secretary of the Party Leadership Group of Shandong Provincial Department of Health.

2015.6 Deputy Secretary and Deputy Director of the Party Leadership Group of Shandong Provincial Health and Family Planning Commission, and Secretary of the Party Committee of the Directly Affiliated Agency.

2016.3 Secretary of the Party Leadership Group and Deputy Director of Shandong Provincial Health and Family Planning Commission.