Researchers believe that screening for changes in proteinuria can help to find those patients with diabetes and prediabetes who are at high risk of stroke. For pre-diabetic patients with proteinuria (especially persistent proteinuria), early intervention should be considered to prevent the disease from progressing and potentially reduce the risk of stroke. The greater the amount of urine protein, the more serious the renal injury. Of course, proteinuria may occur in some non-renal injury cases, such as strenuous exercise, high fever, freezing, renal vein malformation, urine contaminated by blood, pus, sperm, vaginal secretions and so on. But these cases are rare and easy to identify. When proteinuria occurs, the quality of protein entering renal tubular epithelial cells increases, which increases lysosomal activity, suggesting that protein causes lysosomes to overflow into renal tubular cytoplasm, and subsequent cell damage can stimulate inflammation and scar formation.

Affect the growth and development of the human body. In addition, urinary protein also contains immunoglobulin and some trace elements, which will reduce human immunity and lead to the lack of trace elements. At the same time, it will also make patients suffer from hyperlipidemia, increase the viscosity of blood and increase the risk of cardiovascular disease. 1. Glomeruloproteinuria is mainly caused by the abnormality of glomerular basement membrane, and a small part is caused by the change of glomerular capillary pressure. When the permeability of glomerulus increases, protein in blood is filtered by glomerulus, resulting in proteinuria.

Renal tubule is also an important part of the kidney, because when the ability of renal tubule to refilter normal filtered protein decreases, many diseases and causes outside renal tubule will affect the function of renal tubule, such as some hereditary and metabolic diseases and poisoning (cadmium, lead, gentamicin, etc. ).

Decreased protein reabsorption or increased protein secretion leads to increased urinary protein. Such as renal tubular acidosis, nephropathy caused by analgesics and nephrotoxicity of antibiotics. The urine of patients with overflow proteinuria (also known as coagulative proteinuria) is turbid when heated to 40℃, coagulated at 60℃ and dissolved at 100℃.