According to medical research and clinical practice, filling lacrimal groove with hexapeptide is a safe and effective plastic and cosmetic method. Hexagonal peptide is a bioactive peptide, which can promote the production of collagen and the repair of skin. Lacrimal groove filling is to improve the depression of lacrimal groove area by injecting hexapeptide filler, so that the facial contour is fuller and younger. This method has been widely used in clinic, and there is no serious safety problem.