Interferon A recent meta-analysis of 15 studies evaluated the efficacy of interferon. Compared with the untreated control group, the negative conversion rate of HBsAg was 6% higher and that of HBeAg was 265,438 0% higher. The negative rate of HBV DNA was 20% (the detection threshold was 1.5 ~ 30.0 pg /ml or 50 ~ 1 ten thousand copies /ml). If PCR is used, the negative conversion rate of HBV DNA will be reduced. Interferon 5MU daily or 10u three times a week or 1 every other day is a better treatment scheme. The predictor of effective treatment is low viral load (HBV DNA) before treatment.
High-dose interferon is more effective than low-dose interferon, but its side effects also increase. Although the HBsAg negative rate increased significantly after interferon treatment for 4 or 6 months, treatment for 6 months was not more effective than treatment for 3 months. The curative effect of women is better than that of men, and the effective rate of China patients is lower. Among the patients with liver cirrhosis, the patients with severe condition (child-pugh grade B or C) have poor curative effect.
Nucleoside and nucleotide analogues include lamivudine, famciclovir, adefovir, dipivoxil and locavir. They can inhibit HBV DNA replication. In a large-scale randomized controlled clinical trial, patients took lamivudine 100mg/ day orally for *** 12 months, and 16% ~ 32% of patients turned negative for HBeAg, and HBV DNA decreased to.
Combined therapy In some recent studies, interferon (10MU) was given three times a week for *** 16 weeks, and gamasidine was given 100mg daily for 24 weeks, with an effective rate of 29%. In contrast, the effective rate of single drug was 18% ~ 19%, but the difference was not statistically significant.
Antisense oligodeoxynucleotides and ribozyme antisense oligodeoxynucleotides block gene expression through hybridization between antisense strand and antisense strand of HBV DNA. In a recent study, antisense oligodeoxynucleotides inhibited the replication and gene expression of DHBV in Beijing duck for a long time. Ribozyme represents another molecular mechanism to inhibit virus replication. They are antisense oligodeoxynucleotide catalysts that can cleave RNA at specific sites.
The clinical outcome of immunomodulation of acute HBV infection depends on the quality and intensity of host antiviral response. Exactly, HBV in infected hepatocytes may be eliminated by cytotoxic T lymphocytes (CTL), and the possible mechanisms are as follows: ① antigen activated CTL directly kills HBV, leading to the destruction of infected hepatocytes; ② Cytokines secreted by ②②CTL (IFN-γ and TNF-α) can eliminate HBV through noncellular lysis, leading to virus destruction (not destroying hepatocytes), and can eliminate HBV in a large number of hepatocytes by inhibiting virus replication and gene expression. Tolerance is virus-specific, not universal immunosuppression. Many experimental studies show that CD8 ++ and MHCⅰ type ⅰ CTL can clear the virus in infected cells. Therefore, T cell HBeAg epitope vaccine can be used to treat chronic HBV infection.
Thymosin α- 1 can increase the levels of endogenous IFN-α and γ, and also increase IL-2. It can also increase the expression of IL-2 receptor and enhance the proliferation and activity of CD3, CD4, CD8 and NK cells. In HBV infected duck hepatocytes, thymosin α- 1 seems to reduce viral replication, especially at the level of viral protein expression. It is safe, but it needs subcutaneous injection. The results of four studies showed that after 6 months of treatment (1.6mg twice a week), HBeAg and HBV DNA turned negative and ALT decreased to normal in 36% patients. In contrast, only 1 1 1 untreated patients in the control group were effective.
Carefully seek medical advice and choose drugs.
At present, the choice of drugs for treating hepatitis at home and abroad includes three aspects: (1) antiviral drugs; (2) immunomodulators: (3) drugs that promote the repair and regeneration of liver cells.
There are many kinds of drugs for treating viral hepatitis. It is estimated that there are more than 700 kinds of drugs for treating hepatitis in China (including hepatoprotective drugs, antiviral drugs and drugs for regulating immune function). In the treatment of protecting liver function and preventing further necrosis of liver cells, the progress is still remarkable. For example, the mortality rate of severe hepatitis was as high as 80% in the 1960s and 1970s, but it has dropped to about 40% in the 1980s and 1990s, which indicates that the measures to prevent hepatocyte necrosis and promote hepatocyte regeneration have taken a big step forward, but so far there is no specific drug that can radically cure viral hepatitis. However, all kinds of media exaggerated the propaganda of hepatitis treatment, saying that "hepatitis can be cured radically" and "hepatitis * * drugs have the best curative effect" violated the scientific laws, and absurd advertisements were common, such as claiming to be "the king of changing yin", "the bane of hepatitis", "the problem of hepatitis B has been solved", "all the three-yang diseases have turned negative" and "solving the urgent needs of hundreds of millions of hepatitis patients in China".
Recently, many hepatitis experts called on the media to publicize correctly and not to mislead patients into being deceived. It is pointed out that the treatment purpose of hepatitis B is not to make all kinds of virus markers negative, but to prevent hepatitis from developing into chronic and fibrosis. At present, there is no "magic medicine" to eliminate the spread of hepatitis B virus, and there is no provision to take the negative mark of hepatitis B virus as the treatment standard. As mentioned above, although there are many drugs for treating viral hepatitis, especially chronic hepatitis, so far no drug can radically cure hepatitis B virus. For this reason, the author thinks that people with hepatitis B "big three-yang", "small three-yang" and "1.5-yang" or patients with slightly elevated transaminase and hepatitis C transaminase should not ask for help everywhere, such as "the king of turning negative". Our countermeasures are: giving priority to basic treatment, that is, proper rest, keeping optimistic mood, reasonable diet, supplementing enough nutrition and choosing appropriate health food, which has a very good effect on protecting liver function and preventing chronic hepatitis and fibrosis. For those patients with severe hepatitis, it is best to be hospitalized for systematic treatment.
References:
August 20, 2000 Author: Xiao Shansou … Source: China Medical Tribune.
Attached:
Chronic hepatitis refers to acute hepatitis patients who still have clinical symptoms and abnormal liver function after 6 months, mainly manifested as loss of appetite, fatigue, fatigue, or epigastric discomfort, and severe cases such as emaciation, dull complexion and jaundice. Liver function is obviously abnormal, especially the increase of transaminase in the body. Traditional Chinese medicine believes that acute hepatitis can't be cured for a long time, damp heat remains, liver disease spreads to the spleen, and qi stagnation and blood stasis become chronic hepatitis. The effective remedies commonly used in clinic to treat this disease are as follows.
[Party A]
500 grams of Sedum sarmentosum, 500 grams of absinthe and 250 grams of lowland tea. The above medicines are processed into brown granules, each bag weighs13g; Take it with boiling water, L bag each time, 3 times a day, instead of tea.
This prescription has a good effect on chronic hepatitis.
[second party]
500g of Polygonum cuspidatum root, 250g of Schisandra chinensis and 30g of honey10/kloc-0. Wash Polygonum cuspidatum and Schisandra chinensis, put them in a casserole and soak them in water for half an hour, the amount of water is equal to the degree of drug immersion, boil them on medium fire, fry them for half an hour, and filter out the juice when 1 large bowl of liquid medicine remains; Add 2 bowls of water, decoct the juice twice, and when the liquid medicine remains about 1 bowl, filter out the waste residue; Finally, pour the head, the second juice and the honey into a big casserole, cook for 5 minutes with low fire, leave the fire, cool, put the bottle cap tightly, 1 spoon each time, three times a day, and take it with boiling water after meals. Two months is 1 course of treatment.
This prescription is suitable for chronic hepatitis, and has the functions of softening the liver and detoxifying, eliminating rash and relieving pain, and promoting diuresis.
[Third Party]
Rice vinegar 1000ml, fresh pork bone 500g, brown sugar and white sugar120 g. * * * Boil for 30 minutes without adding water, then take it out and filter it, 30-40ml for adults.
This prescription can be used to treat acute and chronic infectious hepatitis.
[fourth party]
Hu Aishan and Garden have 15-25g meat and 1 water fish (i.e. soft-shelled turtle) respectively. Firstly, the water fish is blanched with hot water to urinate, and then the intestinal cavity is removed by incision and cleaning. Then, put the water fish and shells together with yam and garden meat into a stew pot, add a proper amount of water and stew in water.
This prescription is suitable for chronic hepatitis with deficiency of both qi and blood.
[Wu Fang]
30-120g of Radix Aconiti Lateralis Preparata, 9g of Radix Gentianae, 9g of Raphani, 9g of Tribulus Terrestris, 30g of Concha Haliotidis, 9g of Ligustrum lucidum, 9g of Radix Curcumae, 9g of Radix Angelicae Sinensis, 9g of fried atractylodes, 6g of dried ginger, 9g of Cortex Moutan and 6g of raw licorice. Decoct radix Aconiti lateralis Preparata, Zingiberis rhizoma, Glycyrrhrizae radix and concha Haliotidis for 2-3 hours, then decoct for 65,438+0 hours, with 65,438+0 doses per day, and take it in the morning and evening.
This prescription is Lu Zhen's experience in treating chronic persistent hepatitis, which has the functions of warming yang, benefiting yin and enriching soil fertility.
[Sixth Party]
Morinda officinalis 15g, Epimedium15-30g, Buxus japonicus 30g, Taxilli 30g, Salvia miltiorrhiza 30g, Pericarpium Citri Tangerinae 6g, Polygonum cuspidatum15-20g, Scutellaria baicalensis 0/5-20g. Decoct with water, daily 1 dose; Take it twice.
This prescription is Wang Yinglun's prescription for treating chronic hepatitis B, which has the functions of warming kidney and strengthening spleen, eliminating dampness and promoting blood circulation.
[Fang Qi]
Angelica sinensis, Atractylodes macrocephala, Bupleurum 65438 00 grams each, Poria cocos, Polygonum cuspidatum 65438 05 grams each, Herba Artemisiae Scopariae 20 grams, Herba Hedyotidis Diffusae 30 grams, and Radix Glycyrrhizae 6 grams. Decoct with water, daily 1 dose, 1 month is 1 course of treatment.
This prescription is Zhong Lei's proven prescription for treating chronic viral hepatitis B, which has the functions of clearing away heat and toxic materials, promoting blood circulation and regulating liver.
[Eighth Party]
Bupleurum, Fructus Aurantii, Rhizoma Chuanxiong and Rhizoma Cyperi 12g, Radix Curcumae, Radix Pseudostellariae and Poria 15g, Pericarpium Citri Reticulatae and Rhizoma Pinelliae 12g, Atractylodis Macrocephalae and Scutellariae Radix 15g. Decoct with water, daily 1 dose, and take it in the morning and evening.
This prescription is Wang Yuqun's prescription for treating chronic persistent hepatitis, which has the functions of soothing liver, regulating qi, invigorating spleen and regulating stomach.
[Fang Jiu]
Herba Lysimachiae Christinae, Semen Plantaginis (bag), Rhizoma Alismatis and Coicis Semen each 12g, Semen Cassiae 15g, Fructus Crataegi 12g, Cortex Moutan 10g, Radix Salviae Miltiorrhizae 15g, and Herba Hedyotidis Diffusae 15g. Decoct with water, 1 dose, twice a day.
This prescription is Chen Zengtan's prescription for treating chronic hepatitis B, which has the functions of eliminating internal evils, strengthening the body resistance and tonifying deficiency, and regulating qi and blood.
[square stone]
Semen Platycladi and Semen Ziziphi Spinosae each 12g, Radix Asparagi 10g, Radix Ophiopogonis and Radix Angelicae Sinensis 12g, Fructus Schisandrae 9 g, Radix Rehmanniae 14g, Radix Codonopsis 12g, Radix Scrophulariae 10g, and Radix Salviae Miltiorrhizae/kloc-. Decoct with water, daily 1 dose, twice.
This recipe is effective for chronic persistent hepatitis by nourishing the heart and calming the nerves, and treating yin-softening liver. It is the experience of Xi Caikun, a Chinese medicine department of Air Force Hengyang Hospital.
[Fang Xi]
Radix Astragali and Radix Codonopsis 15g, Coicis Semen 30g, Rhizoma Paridis and Radix Paeoniae Alba 10g, Radix Salviae Miltiorrhizae 15g, Rhizoma Osmundae 10g, Herba Artemisiae Scopariae 30g, Fructus Ligustri Lucidi and Bombyx Batryticatus 15g, Atractylodis Rhizoma and Fructus Toosendan 65438+. Decocting in water for 30 days is a course of treatment 1. Effective after 3-4 courses of treatment. After the prescription takes effect, it is changed to honey pills to consolidate the curative effect.
This prescription is proved by Liu Yufu, a Hubei traditional Chinese medicine, which has the effects of invigorating qi, tonifying middle warmer, soothing liver and promoting blood circulation, and is suitable for chronic hepatitis B.
[party 12]
30g of Adenophora Adenophora, 5g of Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Lycii, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Carapax Trionycis preparata, Endothelium Corneum Gigeriae Galli, Dendrobium huoshanense10g, 5g of Notopterygii Rhizoma, and 0g of Radix Curcumae and Pericarpium Citri Tangerinae10g. Decoct with water, daily 1 dose, twice.
This prescription is prescribed by Du Jianmin, a famous old Chinese medicine practitioner in Hubei Province, and has the function of nourishing yin and liver. It is used to treat chronic hepatitis with liver and kidney yin deficiency, with symptoms of bilateral dull pain, bitter taste and dry throat, fever in hands and feet, dizziness and body sound, insomnia and dreaminess, soreness in waist and knees, red tongue, little or thin yellow fur and thready pulse.
Sauté ed Rhizoma Coptidis with wine to clear away heat, Semen Ziziphi Spinosae amber to soothe the nerves and insomnia, Three Immortals Abdominal distension and poor luck, Peach Blossom, Red Flower and Sanqi to promote blood circulation and dredge collaterals are used for patients with chronic hepatitis and early cirrhosis.
Taboo: it is not suitable for people with damp-heat in liver and gallbladder and deficiency cold in spleen and stomach.
[Fang XIII]
9 grams of Bupleurum, 20 grams of Herba Artemisiae Scopariae, 0/5 grams of Radix Isatidis/kloc-,9 grams of Radix Angelicae Sinensis, 20 grams of Radix Salviae Miltiorrhizae, 9 grams of Rhizoma Curcumae, Radix Codonopsis and fried atractylodes, 20 grams of Radix Astragali and Fructus Ligustri Lucidi, 0/5 grams of Fructus Schisandrae Chinensis/kloc-and 9 grams of Poria. Decoct with water, daily 1 dose. Mix the first decoction and the second decoction in liquid phase and take them in the morning, at noon and at night. Can also be ground into honey pills, each weighing 9 grams, take 3 pills a day.
This prescription is Zhou Xin's prescription, which is called Ganxiao. Has the effects of soothing liver, relieving depression, promoting blood circulation, removing blood stasis, eliminating pathogenic factors, invigorating spleen and tonifying kidney, and can be used for treating chronic hepatitis, viral hepatitis, early cirrhosis, hepatosplenomegaly and abnormal liver function.
For patients with damp-heat or cholestasis, 40-60 grams of Herba Artemisiae Scopariae can be reused in the prescription to clear damp-heat, and Radix Paeoniae Rubra and Fructus Gardeniae can be added to remove blood stasis and benefit gallbladder. Epimedium, Rhizoma Curculiginis, and Cinnamomum cassia are added to warm and tonify kidney yang, and Radix Rehmanniae is added to yin deficiency. Lycium barbarum and so on. To nourish kidney yin. For ascites caused by decompensated cirrhosis, blood stasis and yang deficiency, according to the principle of "removing blood stasis and promoting tissue regeneration, warming yang and promoting diuresis", on the basis of reusing products for invigorating spleen and kidney, promoting blood circulation and removing blood stasis, we should also add products for regulating qi and promoting diuresis, such as Pericarpium Arecae, Poria, Alisma orientalis and Lalang Grass Rhizome. To treat both the symptoms and root causes is beneficial to eliminate ascites and restore the compensatory function of the liver.
[Fang 14]
Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria each 65438 05g, Radix Glycyrrhizae 6g, Rhizoma Polygonati, Radix Adenophorae each 65438 05g, Radix Ophiopogonis 65438±00g, Fructus Lycii and Radix Paeoniae Alba each 65438 05g. Take the medicine * * * and decoct it, each time 1, mouth 150ml. Take 1 time in the morning and evening.
This prescription is Wang Qiaochu's prescription, which has the functions of invigorating spleen and qi, promoting fluid production and nourishing liver. It is suitable for patients with acute viral hepatitis in recovery period and those with chronic viral hepatitis due to liver disease, spleen deficiency, liver yin damage and lingering.
If jaundice persists, GFI is still abnormal, and residual pathogenic factors of damp-heat are still unclear, Lysimachia christinae, Plantago asiatica and Radix et Rhizoma Rhei are added to clear away damp-heat, promote gallbladder function and relieve jaundice; Radix Bupleuri, Radix Curcumae, and Fructus Aurantii are added to patients with liver depression and qi stagnation syndrome to soothe the liver and regulate qi; For patients with severe pain in the liver area, Jin Lingzi and Yuanhu are added to relieve pain; People who are disturbed by liver yang are irritable, restless at night and flustered. MUBI adds Os Draconis, Concha Ostreae, Concha Margarita, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae and Caulis Polygoni Multiflori to calm the liver and soothe the nerves.
[Fang XV]
500 grams of pork, 500 grams of fresh Pleurotus ostreatus, cooking wine, refined salt, onion, ginger slices and raw oil. Wash the pork, blanch it in boiling water for a while, take it out and cut into pieces. Wash the oyster mushrooms with water. Add cooking oil into the pot, stir-fry ginger and onion when the oil is hot, add human flesh pieces, cook cooking wine, stir-fry until the water is dry, add water and refined salt, boil over high fire, and simmer until the meat is cooked, but stew with mushrooms until the Pleurotus ostreatus is cooked and tasty.
Mushrooms contain high carbohydrate and various amino acids needed by human body, which are not only delicious, but also have a good therapeutic effect. It has good curative effect on hepatitis, gastric ulcer, duodenal ulcer, chronic gastritis, rickets and hypertension, can regulate female climacteric syndrome, improve human metabolism, enhance physical fitness, and contains some anticancer substances, which can be used as health food for preventing cancer. If it is matched with pork, it can improve the nourishing and health care effect of Pleurotus ostreatus.
[Parties 16]
500 grams of loach, 250 grams of tofu, and the right amount of salt. Remove gills and viscera from loach, wash it, put it in a pot, add water, cook it until it is half cooked, add tofu and salt, and stew it until it is cooked.
This prescription has the effect of clearing away dampness and heat, and is suitable for damp-heat jaundice, dysuria and infectious hepatitis.
This prescription comes from Quanzhou Materia Medica and is called Houbu. The original prescription is used for "jaundice, damp heat and urination". Prescription for treating damp-heat jaundice. Damp-heat fumigation, bile leakage and jaundice should be treated by clearing away damp-heat. Misgurnus anguillicaudatus is the main prescription, which can clear urine and remove damp heat, especially for jaundice; Taking tofu as an assistant, clearing away heat and toxic materials to help clear damp-heat, a recipe for clearing damp-heat is produced.
[Fang 17]
250 grams of live carp, 40 grams of sugar, 500 grams of vegetable oil (actually consumed 50 grams), onion, ginger and garlic 10 grams, 40 grams of flour, 5 grams of dry flour, 8 grams of bamboo shoots, 0. 15 grams of dried fungus, soy sauce 15 grams, and vinegar.
Blanch dried auricularia auricula with boiling water, cut onion, ginger and garlic into filaments, cut water chestnut and bamboo shoots into thin slices, and mix flour with water above 1 time to make wet flour; Slaughter live carp, remove scales and dig gills, take out internal organs, clean and dry them, then cut both sides of the fish into 5.6 cm knives, sprinkle refined salt on the knives first, marinate them slightly, then evenly spread dry flour on each knife, and then evenly spread flour on both sides of the whole fish; After the oil pan is boiled, put the fish into the oil pan, and the knife edge on the fish will be opened immediately, and the fish tail will be tilted. Keep shoveling the bottom of the pan with a knife to prevent the pan from sticking. At this time, you can push the fish tail to the side of the pot, let the fish body bend slightly, turn it over and fry it, then flatten the fish body, press the fish head into the oil and fry it thoroughly. When it turns golden yellow, take it out, filter to remove oil and put it in a plate; Then take a small amount of vegetable oil, add onion, ginger and shredded garlic, add vinegar, and at the same time add fungus, bamboo shoots, water chestnut, broth, cooking wine, sugar and wet flour, burn it into thick juice, and quickly pour it on the fried fish. Eat dinner once a day 1 time.
It contains protein 3 1. 1 g, fat 58.6 g, sugar 76 g, calorie 956 kcal, calcium 434 mg, phosphorus 397 mg, iron 5.7 mg, thiamine 0. 1.8 mg and riboflavin 0. 1.9. ..
This product is applicable; Factory patients with coronary heart disease, hypertension, cerebrovascular disease, malnutrition, dyspepsia and liver disease.
[Party 18]
50 grams of yam, 2 egg yolks, and 0/50 grams of japonica rice/kloc. Beat the eggs, remove the white and leave the yellow, beat the yolk with chopsticks, wash the yam and slice; Japonica rice is washed clean. Put yam and japonica rice together in the pot and add appropriate amount of water. Bring the pot to a boil with high fire and cook it with slow fire until cooked. Before taking out the pot, pour the egg yolk into the porridge, then stir well and bring to a boil.
This recipe has the functions of nourishing yin, moistening dryness, nourishing blood and calming wind. It is the best diet for middle-aged and elderly people with weak constitution in spring. Can be used for adjuvant treatment of vexation, insomnia, fever, spasm, syncope, fatigue, hematemesis, vomiting, diarrhea, fetal leakage and bleeding, scald, hepatitis, and infantile dyspepsia.
References:
/Article/class 190/ Yan Fang/gandang/200407/58815.html.