Action mechanism of 1
When the machine is injured, the tissues or cells around the injured site will secrete a variety of wound healing factors, such as EGF, bFGF, PDGF and TGF-β. These factors have little content, but they play an extremely important role in wound repair. Among them, bFGF has the widest scope of action, which can promote the proliferation and division of almost all cells related to trauma, such as fibroblasts, vascular endothelial cells, smooth muscle cells, epithelial cells, chondrocytes and nerve cells. The mechanism is that bFGF receptors are widely distributed on these cell membranes. It has high specificity and affinity for bFGF receptor. When bFGF specifically binds to the receptor, it activates intracellular protein kinase through the information transmission system in the cell membrane structure, and then causes various physiological and biochemical reactions in the cell, and finally realizes the regulation of cell growth. BFGF can significantly promote three stages of wound repair, namely, local inflammatory reaction stage, cell proliferation and differentiation stage, granulation tissue formation stage and tissue reconstruction stage.
1. 1 local inflammatory reaction stage: bFGF has obvious trend activity on wound cells, inducing inflammatory cells, fibroblasts and vascular endothelial cells to move to the wound site, activating the phagocytic function of macrophages, improving the immune activity of the body and obviously reducing the chance of wound infection.
1.2 Cell proliferation and differentiation and granulation tissue formation stage: In the cell proliferation and repair stage, granulation tissue formation is one of the most critical steps. The essence of granulation tissue is a large number of capillaries and abundant fibroblasts. BFGF is an efficient growth agent for fibroblasts, vascular endothelial cells and vascular smooth muscle cells, which can strongly promote the formation of new capillaries and significantly increase the number and blood flow of capillaries in granulation tissue. Improve wound microcirculation and provide necessary oxygen and rich nutrition for tissue repair. Fibroblast is also the main cell to synthesize collagen, which is the main component of granulation tissue intercellular substance. BFGF can continuously improve the structure and strength of the repaired tissue by regulating the continuous synthesis, secretion, remodeling and renewal of collagen. At the same time, bFGF can also stimulate the expression of collagenase. Therefore, it can effectively inhibit pathological scars caused by massive synthesis and excessive precipitation of collagen, thus improving the quality of wound healing. BFGF can also significantly promote the regeneration of nerve fibers in injured tissue, and accelerate the recovery of injured tissue function by improving tissue nerve reinnervation.
1.3 Tissue reconstruction stage: bFGF can accelerate wound healing by promoting the rapid proliferation of epithelial cells, covering the wound center. Although the body can spontaneously secrete a small amount of growth factors such as bFGF when it is injured, it plays a role in self-repair. However, experiments have proved that spontaneous wound repair is far from the maximum speed, and the growth factors in its molecular environment have not reached the optimal level. Especially various refractory chronic wounds. Because some cells in the body are inhibited and lose the function of secreting growth factors, it is difficult for the wound to heal for a long time.
2 Clinical evaluation
2. After treatment with1bFGF, the healing time (days) of burn wounds or fresh wounds with different depths between the administration group and the negative control group was significantly different.
2.2 After treatment, the healing of chronic wounds is especially accelerated.
2.3 For different types of wounds, the healing of fresh wounds, burned wounds and chronic wounds can be accelerated gradually in advance after treatment with bFGF, which may be related to the amount of bFGF in the wounds themselves and the addition of bFGF. Fresh wounds contain bFGF, and adding bFGF is not the main factor to start healing, while in chronic wounds, there is little or no bFGF, and adding bFGF plays a starting role.
2.4 The cure rate of laser ulcer in genitourinary system is as high as 90%, and the effective rate is 100%. Condyloma acuminatum is a common sexually transmitted disease, and it is easy to recur. The recurrence rate after laser and other surgical treatments is as high as 90%, and the recurrence rate of patients with chronic ulcers is even higher after laser treatment. BFGF can promote the rapid healing of laser-induced ulcer, which is of great significance to improve the cure rate of condyloma acuminatum and reduce the recurrence rate.
2.5 Application evaluation of patients with oral diseases
① Treatment of vital pulp preservation: early pulpitis and accidental perforation, bFGF can promote the activity of pulp fiber cells, repair pulp perforation, control inflammation and achieve the purpose of preserving vital pulp. ② Damage caused by nonspecific infection of oral mucosa: erosion, ulcer, etc. Can be applied. ③ Treatment of periodontal disease: The purpose of periodontal disease treatment is to regenerate the damaged periodontal tissues: cementum, periodontal ligament and alveolar bone, and form attachment. The application of bFGF aims to guide periodontal ligament cells to migrate and grow to the crown and gather in the root area, and promote the formation of new cementum, periodontal ligament and alveolar bone. ④ Application of plastic surgery such as cleft lip and palate: promoting wound healing, especially the application of bFGF in cleft palate and relaxed incision, can promote the growth of new granulation tissue.
3 Clinical application
3. 1 various acute and chronic body surface ulcers (including diabetic ulcers, radiation ulcers, bedsores, fistula, etc.). ).
3.2 Fresh wounds (including trauma, knife wounds, frostbite, laser injuries, donor wounds, surgical wounds, etc.). ).
3.3 Burn and scald (superficial second degree, deep second degree, granulation wound, etc. ).
4 Preventive measures
4. 1 Do not place this product in high temperature or frozen environment.
4.2 This product is sterile. Please cover the nozzle immediately after use.
4.3 High concentration protein denaturants such as iodine, alcohol, hydrogen peroxide and heavy metals may affect the activity of this product. Therefore, after routine debridement, it is recommended to rinse with normal saline before using this product.
4.4 For infectious wounds, local or systemic antibiotics can be used as appropriate.
The BFGF stock solution itself is a fake, because it is impossible for growth factors to exceed the validity period of 7 days in liquid state.
One more thing, bFGF has become a national first-class new drug since 2004, and it is impossible for cosmetics factories to produce and repackage it.
The unwinding of BFGF stock is even more absurd, and it can only be fooled by some uninformed people.