Collagen injection can be used to remove wrinkles and repair facial wrinkles and soft tissue defects. Its trade name is ZCI (ZDERM Collage Implant). ZCL has the same composition as human collagen, so it has good compatibility, minimal foreign body reaction and hypersensitivity, and its hardness is similar to the structure of the tissues around the injection site. No carcinogenicity, can be disinfected for later use. In order to eliminate wrinkles, collagen should be injected into the superficial dermis. There will be local pitch during injection. When collagen overflows from sebaceous glands, it means that the injection amount is sufficient. Within 2 1 h of injection, the injected collagen volume decreases due to water absorption, so it is often necessary to straighten the rod.