Diabetes is a metabolic disorder that causes systemic damage to the human body. This process is relatively slow, and it often takes many years for serious consequences to appear. These consequences can be collectively referred to as complications of diabetes, and vascular damage is one of the major damages. After blood vessels are damaged, tissues and organs will not be adequately supplied with nutrients, and a series of problems will inevitably occur. In the early stage, it may be dysfunction, and in the severe stage, it may be necrosis. Elevated blood sugar leads to an increase in blood viscosity, which can lead to intra-arterial thrombosis; too much sugar in the blood combines with hemoglobin, which can affect the ability to transport oxygen, leaving tissues and organs in a state of hypoxia; excessive blood sugar leads to an increase in toxic metabolites in cells , causing cell damage, thereby affecting vascular function; high blood sugar stimulates the proliferation of the vascular intima, leading to narrowing of the lumen and reduced elasticity, which can seriously affect the blood supply; abnormal glucose metabolism leads to abnormal lipid metabolism, which can lead to the occurrence of arteriosclerosis and speed up its process. Under the combined effect of these factors, the body's arterial system can gradually be damaged, affecting the blood supply. The lower limbs are in a remote area relative to the heart, and the logistics supply line is long, so there are naturally many opportunities to be affected. The first problem that manifests itself is the problem of the toes, which are located at the "most frontier", and then the entire foot, so "diabetes" appears. The concept of "feet": First, when I go to bed at night, my feet feel cold, hot water soaking does not work, and covering the quilt with a quilt does not work overnight; then my calves are tired when walking, and I can only stop and go; then there is pain in the lower limbs; finally, there is pain in the lower limbs. Blisters, ulcers, infection, ulcers, and blackening (gangrene) of the skin on the toes. As the disease gradually develops, gangrene starting from the toes can gradually develop upwards, and in severe cases can cause necrosis of the entire limb. At this time, it has threatened human life, and amputation has become the only way to save life. According to statistics, patients with diabetic foot account for 10% of all hospitalized patients with diabetes, and 3% of them require amputation. Among people over 50 years old, the amputation rate among diabetics is 40 times higher than among normal people.

So, after the onset of diabetic foot, is amputation necessary? Of course not. Amputation is not a solution, and drug treatment of the original disease is the main measure, which can delay the development of vascular lesions. But if drugs have little effect, vascular surgery may also have a certain effect.

Since diabetic foot is caused by insufficient blood supply to the feet, wouldn’t it be possible to solve the problem by diverting blood to the feet through artificial bypass? Yes. This is a traditional surgical procedure that has been performed by surgeons for many years. When bypassing a bridge, it must cross diseased and narrow blood vessels, from the root of the thigh to the ankle, otherwise it will affect the distant blood supply. Generally speaking, the farther the bridge is built, the better the effect of protecting the distal limbs. Building a bridge means doing construction. Where do the materials come from? The easiest thing to think of is artificial blood vessels. After many years of use, it has been found that artificial blood vessels work well when used short distances. If they are too long, there is a higher chance of internal thrombosis causing obstruction. Artificial blood vessels often collapse and cause obstruction where they cross the knee joint. Another material is the patient's own material. The great saphenous vein running through the entire length of the lower limb is ideal. However, it has been found in application that the great saphenous vein also has certain shortcomings, that is, the caliber is relatively small, and the blood supply is often not large enough. In addition, a considerable number of patients also have problems with the great saphenous vein itself, making it difficult to obtain the length of a leg. Dr. Fredman of Boston University in the United States combined the two materials. The section above the knee is made of artificial blood vessel material, and the section spanning the knee and below the knee is made of the great saphenous vein. This is called sequential bypass surgery, which not only meets the blood supply, but also uses artificial blood vessels. It also reduces the chance of blockage, has wide adaptability, and has been rapidly promoted internationally. During our application, we found that the joint of the two-section graft and the distal joint were the key to the operation, so we made improvements in these two parts. The joints of the two materials were originally connected to the human artery at the same time. Instead, the artificial blood vessel was connected to the artery itself, and then the great saphenous vein was connected to the artificial blood vessel. This has certain benefits in improving the smoothness of local blood flow. ;The joint at the distal ankle is expanded, changing the blood flow direction of the vein accompanying the artery, so that the injection point of the great saphenous vein changes from one point to two points, and the foot steps on two boats, creating a *** Co-flow channel technology drives blood flow.

As the foot regains sufficient blood supply, the dying cells and tissues in the ulcerated toe area quickly regain their vitality, and the ulcer can heal quickly. The patient felt that his feet were much warmer and his calves no longer hurt when walking. For toes or part of the toes that have become necrotic, of course it is impossible to revive the dead ones, but due to the abundant blood supply, the edges of the necrotic area no longer continue to spread upward, and the dividing line between normal and abnormal tissues becomes more and more obvious. Finally, the necrotic toe can fall off on its own. When it is difficult to fall off, it is enough to use surgical methods to remove the necrotic part. This avoids the high-level amputation of "losing the leg because of the foot", fully retains the function of the limb, and improves the patient's quality of life. There are very big benefits.

China has "bloodletting therapy", which is to use

needles on or under the patient's necrotic skin to release the congestion and take away the necrotic tissue, and the foot ulcer will gradually heal. improve.

A patent has alleviated the pain of thousands of people suffering from skin ulcers

Reading Tips By chance, physician Zhang Ping made up his mind to delve into the medical problem of skin ulcers. After continuous improvement, her set of formulas and treatments have become increasingly mature, and she has obtained a Chinese invention patent.

So she changed her career to become a specialist doctor, and now it has developed into a large-scale specialist hospital, relieving the pain of tens of thousands of patients. The story tells us: The emergence of excellent patent results is both accidental and inevitable; and from the creation to the implementation of patents and the broad benefits they achieve, a peaceful mind is needed. Before interviewing Jinan Skin Sore Hospital, the reporter had obtained a piece of information about the hospital. In the thick folder, apart from simple written information, the rest are all photos of the parts of patients with skin sores. The ulcerated wounds and bloody limbs can only be described as "horrible". It is unimaginable how the patients endured such physical and psychological torture. Data show that non-healing wounds and skin ulcers caused by various reasons are difficult issues in the field of medical research today. Clinical treatments generally include skin grafting, amputation, or declaration as an incurable disease; many patients face amputation. Or the tragedy of paying the price with lives. However, Jinan Skin Sore Hospital has created the medical myth of "turning decay into magic". Many patients from all over the country who were about to have their limbs amputated have been carefully treated by the hospital, and most of them have saved their limbs; for more than ten years, , patients with wounds that had not healed for decades regained normal skin. This comes from a Chinese invention patent by Dean Zhang Ping - "Ji Sheng Ji Yu Pi Cream". Love drives physicians to fill in the blanks. "This is not a secret recipe passed down from ancestors. I worked it out slowly by myself." In the simple office of the director of Jinan Skin Sore Hospital, Zhang Ping talked to reporters about her patent. Zhang Ping is a member of the generation who grew up during the Cultural Revolution. As a worker, peasant, and soldier student in that special era, her total theoretical and practical time in the medical school was only two years. After graduation, he was assigned to Jinan Lixia District Hospital and became a physician. In the early 1980s, an old lady asked Zhang Ping to change her dressing during the Spring Festival, and she agreed. At that time, the old man had an ulcerated wound on his foot as big as his thumb, which required frequent dressing changes. When she learned that the wound had not healed for eight years, Zhang Ping immediately aroused curiosity. As a physician, she had neither learned about this kind of chronic skin ulcer in class nor seen it in relevant materials. In the next few days, she tried to give the old lady several different medicines, but none of them worked. A doctor told her that he would give a plaque to anyone who could cure the wound. Zhang Ping realized that there was still a medical gap in the treatment of this disease. Zhang Ping, who likes challenges, consulted relevant experts everywhere in the following days and read ancient books and documents every day. From Chinese and Western medicine dispensing to folk remedies, she studied one by one, and finally reached the point of obsession. Sometimes I would sleep until midnight and suddenly have an idea, so I would wake up my sleeping husband to help. Regarding the final success of this formula, Zhang Ping joked that she was a "blind cat catching a dead mouse" because in just half a year, the drug achieved satisfactory results, and the old lady with a foot ulcer ended her eight-year illness. Sickness. With her first success, Zhang Ping paid more attention to those patients with skin ulcers. Once, she saw a patient in the hospital's surgery department who was wearing a cast for a broken bone and had a large area of ??skin sores. With the attitude of giving it a try, she recommended that the patient use her formula. The result was equally successful. Since then, she has continued to refine and perfect the recipe. In her spare time, she constantly visits the surgical ward of the hospital and often visits patients' homes to practice medicine. Slowly, she gradually summarized a "trinity" therapy of oral Chinese medicine, external Chinese medicine and intravenous drip. Degao’s patented medical expertise has made private hospitals miracles continue to appear, and their impact is growing. Later, with the support of the hospital, Zhang Ping took a leave of absence without pay, rented a hospital ward, and established a "Skin Sore Treatment Center." Once, one of her patients said to her that your prescription is so good that it should be protected by a patent. This was in 1993, and most people had no idea what a patent was. Zhang Ping followed his advice, compiled her own prescription, and went to the Shandong Provincial Patent Office to apply for an invention patent. In 1997, her invention patent "Ji Sheng Yu Pi Cream" was authorized. The so-called skin ulcers are caused by diabetes, varicose veins of the lower limbs, vasculitis, bedsores, burns, frostbite, traumatic fractures, osteomyelitis, non-healing incisions after surgery, mosquito bites, anal fissures, anal fistulas, hemorrhoids, genital inflammation, etc. Skin ulcers caused by various reasons that cannot be cured for a long time have a high incidence rate. As Zhang Ping's popularity continued to increase, the rented hospital outpatient rooms were no longer enough. With the help of relatives and friends, she purchased a simple three-story building in Lixia District, Jinan City, and founded " Jinan Skin Sore Hospital". As the number of patients continued to increase, the three-story building became cramped, so she converted the hospital into a six-story building. So far, more than 90 hospital beds are still far from meeting clinical needs. She is actively planning to expand the hospital. "We have statistics. Except for Tibet, there are patients coming to seek medical treatment from other provinces and cities across the country." Zhang Ping said. Since she invented this formula in 1985, tens of thousands of patients have been treated here, and most of them have recovered. Creating a myth and writing a legend in a characteristic hospital. Zhang Ping's office is filled with photos of patients with skin sores. At a glance, most of the walls are filled with horrifying pictures. A doctor from the hospital said frankly that it would be "hard to bear" for people who have never been a doctor to look at these photos. But in Zhang Ping's eyes, these photos have different meanings. Perhaps they represent a kind of responsibility and a kind of care. The patient, Dong, comes from Guide Town, Changqing District, Jinan.

In the summer of 1996, Dong felt pain in his left shoulder. After treatment at a local hospital, the pain worsened, accompanied by redness and swelling. Soon, the muscle tissue began to turn black and ulcerate. Dong's family hurriedly took him to a provincial hospital in Jinan, where he was diagnosed with "arteriovenous cellulitis." In just a few days, I watched the muscle ulcers in the entire left arm continue to spread, causing severe acute heart failure, acute renal failure, severe anemia and other complications. The hospital issued a critical illness notice. In despair, Dong and his family came to Jinan Skin Sore Hospital with good luck. At that time, Dong's entire left arm skin and muscles were extensively necrotic, with more than 80% necrosis in a honeycomb shape and extending to his armpits. His face was bruised and severely deformed. Faced with this rare disease, all the medical staff present were stunned. Zhang Ping and experts from the hospital immediately consulted and formulated a rescue plan. A week later, new granulations appeared on the patient's affected limb, the honeycomb necrotic tissue gradually disappeared, and the complications began to improve. After half a month, skin began to grow around the wound. Four months later, Dong miraculously recovered. Ms. Su from Jiamusi City, Heilongjiang Province, came all the way to Jinan with her elderly mother to seek medical treatment. Ms. Su told the experts that her mother's left foot had a scar due to burns 30 years ago. Seven years ago, a small crack appeared on the scar, which gradually expanded and continued to fester. In order to treat her mother's illness, Ms. Su took her mother to various parts of the country to seek medical advice. However, they were disappointed again and again. Ms. Su, who was eager to treat her mother, searched extensively on the Internet for hospitals that could treat this disease. When they saw the information that Jinan Skin Sore Hospital could treat skin ulcers, they came to Jinan with the mentality of giving it a try. In just 9 days, bright red granulation tissue appeared on the ulcerated feet, and the skin gradually healed. The mother and daughter never dreamed that they would finally see hope here after seven years of illness. On the wall of the hospital office, there is a banner presented by an old general of the Jinan Military Region: "Exquisite medical skills, the crown of the apricot forest." It turned out that two years ago, the general's wife suffered from diabetic gangrene in her left foot, causing toe necrosis and ulceration. The military hospital diagnosed her as requiring amputation. After learning the news, although the veteran general who had spent his whole life in the military endured his grief and tried to comfort his wife to accept this cruel reality, he still couldn't bear to let his wife leave the regret of being disabled in his later years. After being introduced, Zhang Ping was invited to the military hospital for consultation. After careful diagnosis, Zhang Ping believed that the old man's foot did not need to be amputated, and even the ulcerated toes could be saved. For the sake of caution, after agreement with the military hospital, Zhang Ping went to the military hospital for treatment. Two days later, the inflammation in the patient's wound began to disappear significantly. This made the general overjoyed and immediately decided to transfer to Jinan Skin Sore Hospital for treatment. After more than 40 days of careful treatment, the general's wife fully recovered. Experts from the military hospital came after hearing the news. When they saw the effect of the treatment, they repeatedly praised: "Miracle! Miracle!" Zhou, a farm woman from Qufu. In June last year, I accidentally injured my right foot while riding a bicycle. I received 6 stitches at the local health center. After that, the wound never healed. I was treated in local hospitals and many hospitals in Jinan, the provincial capital, but still there was no improvement. In the end, he was diagnosed by a provincial hospital as a non-healing wound caused by diabetes. The only clinical treatment was amputation, otherwise he would pay the price with his life. As a result, she spent more than 60,000 yuan in medical expenses and her right leg was amputated below the knee. This middle-aged farm girl became permanently disabled. But the bad luck had not left her. Soon, the surgical sores began to fester, and high amputation was waiting for her. In despair, Zhou and her husband came to Jinan Skin Sore Hospital with the desire to survive. After learning about the situation, Zhang Ping and her colleagues said regretfully: "If you had come earlier, you wouldn't have lost this leg. What a pity." "The subsequent treatment brought about a miracle again. Seeing the wound healing day by day, Zhou was filled with joy and sorrow. Although he lost a leg, his life was saved, which gave the originally unfortunate Zhou and her husband hope of life. Difficulties in development: It is difficult for private hospitals to break the financial bottleneck. Zhang Ping told reporters that the hospital is in a new stage of development and, like other small and medium-sized enterprises, also faces financial difficulties. This is because they have higher running costs. First, the charges to patients are low; second, they visit hospitals across the country, incurring huge travel expenses; and third, they often waive fees for patients with family difficulties. It is reported that a demobilized soldier who had been "sentenced to death" by the hospital wanted to leave the provincial capital Jinan and go home to "wait to die." The patient's brother inquired about this hospital. When I arrived, my shoulder joint was ulcerated and completely empty. After examination by Dean Zhang Ping, he was diagnosed with "bone tuberculosis". This patient was in critical condition many times during debridement treatment, but it was Zhang Ping and the doctors who rescued him from death. When he was discharged from the hospital, the patient's family was poor and he owed 50,000 yuan in medical expenses. The hospital proposed that only the cost be recovered and the rest of the expenses be exempted. But the patient disagreed and insisted that his life was saved by the hospital and that he could not owe the hospital any money. Finally, 50,000 yuan was collected and handed over to the hospital. Zhang Ping said that this is the highest medical fee she has ever received since she opened the clinic. But she explained that at that time, the cost was relatively high because the hospital's operating room also needed to be rented. Now, the entire treatment cost for most patients is only 3,000 to 4,000 yuan, and the most is only about 10,000 yuan. Over the past few years, the amount of money the hospital has reduced or even subsidized for patients has accumulated to a considerable amount. From outpatient clinics to hospitals, all investments are accumulated slowly. Zhang Ping said that she did not receive any investment during this period.

However, as a private hospital, it is difficult for it to achieve breakthrough development just by relying on its meager accumulation. “There are still a large number of patients in the society waiting for our treatment, and the existing conditions of the hospital are far from meeting the needs of patients. It urgently needs improvement, expansion, additional equipment, introduction of talents, and expansion of popularity, all of which require funds. Zhang Ping finally said, "I hope someone can invest in expanding the scale of the hospital so that more patients can relieve their pain."

Reporter's remarks

The Nth model of patent implementation is in. Among the patent holders contacted by the reporter, there are generally several ways to implement the patent: one is transfer, which is to sell their patent cleanly; the other is cooperation, signing a cooperation agreement with the employer, jointly implementing it, and obtaining Long-term benefits; the third is to implement it yourself, that is, to raise funds yourself and develop your own patented products. Because the nature of patented products is different, various implementation methods have their own advantages and disadvantages in practice. Zhang Ping's way of implementing patents seems to be somewhat special, and reporters tentatively call it the "Nth mode." Its particularity lies in the fact that the implementation of the patent of "Ji Sheng Ji Yu Pi Cream" starts with the smallest investment, slowly accumulates, and gradually expands. Although Zhang Ping also cooperated with a pharmaceutical factory during this period, due to various reasons, she did not receive a profit commission during the contract period. She only received tens of thousands of yuan in cooperation funds according to the contract. Compared with a considerable-scale private hospital, It's obviously not enough. The birth of an original invention patent often embodies the inventor's huge investment of money, time, energy and wisdom. But in many cases, huge efforts do not mean good market returns - this is determined by market needs and project operation capabilities. Practice has proved that "Ji Sheng Ji Yu Pi Cream" has broad market prospects. For now, it is not an extravagant expectation to transfer it for a "sky-high price". But this "sky-high price" was gradually accepted and recognized by society during the process of Zhang Ping's personal implementation. On the other hand, if Zhang Ping directly transfers the patent without clinical practice and asks for millions of dollars, the chance of success may be very small. Perhaps this patent is still dormant. At least tens of thousands of patients have relieved their pain and gained a new life through this patent. From the perspective of contribution to medicine and promotion of the spirit of humanity, the merits are immeasurable and cannot be measured by money. Not every patent's social value can be gradually highlighted like this. As an inventor, Zhang Ping's saving grace is her "peace of mind." "Zhuangzi·Miscellaneous Pian·Lieyu Kou" says: Zhu Pingman learned how to slay the dragon in Zhiliyi, a family with a single daughter. It takes three years to achieve a skill, but there is no use for it. Paying thousands of dollars to learn the art of slaying dragons is an expense that only wealthy families can afford. However, no matter how sophisticated the skills are, once you graduate, you will have nothing to do. It would be better to kill pigs and cows. According to the ancient master-apprentice rules, if you learn to butcher pigs, the most you can do is to work for free with the master, which is very low-cost. After completing your studies, you will be able to support your family soon. You will not become rich, but you will not go hungry either. Where there is demand, there is a market, where there is a market, there is profit, and where there is profit, there is success. This is the most "shameless" rule of the market economy. Therefore, Mr. Liu Xuemin, a well-known management consultant, believes that the teacher Zhi Liyi who can charge thousands of dollars to "sell" the concept of killing dragons is the biggest success in the market economy. Whether a patented project is a "gold bar" or a "straw" is ultimately decided by the market and always depends on the recognition of consumers and the general public. This requires time to test, overcoming numerous difficulties and bold practice, achieving a "peace of mind", constantly improving patented technology, mastering more market information, and grasping more market laws. The most important thing is that it is impossible to "make big money" in this process, otherwise it may go the other way. Even the priceless Heshi Bi may not be recognized by others without careful consideration. This is the important connotation of the Nth mode of patent implementation.