Nano-calcium phosphate collagen-based artificial bone material is a biological tissue repair material based on the study of natural bone microstructure, designed with the idea of structural bionics and prepared by self-assembly method. Materials More than 4,000 operations have been successfully completed since obtaining the clinical permission of the State Medical Supplies Administration. All patients have no adverse reactions after operation and achieved good repair results. The distribution of diseases is as follows: bone grafting and fusion of bone defect of limb fracture, lumbar intervertebral fusion, anterior cervical intervertebral fusion, curettage and fusion of benign bone tumor, bone grafting and repair of aseptic necrosis of femoral head, bone grafting and filling of bone defect in plastic surgery and stomatology, etc. Nano-calcium phosphate collagen-based artificial bone material is a biodegradable material, and the degradation of the material matches the growth of new bone tissue as a whole. After the material is implanted into the body, due to body fluid-mediated dissolution and cell-mediated absorption, many depressions are formed on the surface of the material, and some depressions are gradually filled with new bone tissue. With the further degradation of the material, it is finally replaced by its own bone tissue, similar to the process of bone reconstruction. Calcium phosphate collagen-based artificial bone material is an ideal bone repair material.