Basic overview: Squamous cell carcinoma is a malignant epithelial tumor originating from bronchial epithelium, which can be characterized by keratinization and/or intercellular bridging. Including spindle cell carcinoma, is the most common type, accounting for about 35%-45% of primary lung cancer. Squamous cell carcinoma is generally considered to be related to the environment, especially to the stimulation of sunlight. Long-term sunlight exposure and chronic stimulation are the main potential causes of the disease, and trauma, radiation exposure and tar derivatives can also induce the disease. Discoid lupus erythematosus, chronic ulcer, leukoplakia mucosa, burn scars's disease and long-term unhealed sarcoma can all induce squamous cell carcinoma. Symptoms: Squamous cell carcinoma accounts for about 90% of skin cancer. Squamous cell carcinoma usually occurs between 30 and 50 years old. It is often transformed from precancerous diseases such as keratosis and mucosal leukoplakia. Squamous cell carcinoma is dark red and hard at first, which is higher than the nodules on the skin surface. After that, the cuticle on the surface fell off and appeared red and rotten, accompanied by oozing blood and fluid, and the focus gradually expanded. Squamous cell carcinoma grows rapidly and forms ulcers at an early stage. Some of them are nodular or cauliflower-like, which has less invasion on the deep movable basement; Some are butterfly-shaped, with obvious infiltration into the deep and strong destructiveness, often involving bones. Squamous cell carcinoma is often accompanied by purulent infection, odor and pain. Regional lymph node metastasis and huge squamous cell carcinoma are more common, with incomparable stench, more purulent secretions and easy bleeding; Cervical lymph node metastasis occurred. Squamous cell carcinoma develops fastest at the junction of mucosa and skin, and patients with mucosa are more likely to metastasize. Squamous cell carcinoma mostly occurs on the basis of chronic ulcer, mucosal leukoplakia and xeroderma pigmentosum. The most common parts are eyelids, nose, lips, temples, cheeks, forehead and limbs, and foreskin, glans penis and trunk can also occur. Compared with basal cell carcinoma, squamous cell carcinoma develops rapidly and is prone to metastasis. According to statistics, the metastasis of lower limb skin cancer is more, followed by the back of the hand and the face and neck, and the blood metastasis is rare, and the lung is the most common metastatic organ. The damage of basal cell carcinoma develops slowly, with few regional lymph node metastasis and no distant metastasis. Squamous cell carcinoma of skin is a common skin tumor, and its incidence is second only to basal cell carcinoma of skin. Fibronectin (FN) is a macromolecular multifunctional extracellular matrix (ECM) glycoprotein isolated from LTBM cells in long-term human bone marrow culture system. It can connect various cells, growth factors and other ECM components, attract chemotactic macrophages, play the role of non-specific opsonin, and help macrophages (Mφ), lymphocytes (Lc) and cancer cells to play a cytotoxic role locally. There is a "synergistic transmembrane correlation" between FN and intracellular actin microfilaments, which plays a role related to cell motor function in transformed cells. In this paper, the relationship between the changes of FN in 50 cases of skin squamous cell carcinoma (SSC) and the biological behavior of cancer cells, as well as the reaction of Mφ and Lc in the stroma were studied. Edit this pathological epidermal keratinization. The tumor is composed of squamous epithelial cell mass, which irregularly infiltrates the dermis. The spinous cells are redundant hyperplasia, which are cord-like or nested cell mass with basal cell layer at the edge and keratinized cancer beads at the center. There are many mitotic images in the cancer cells, and the surrounding lymphocytes and plasma cells infiltrate. Clinical diagnosis: generally divided into 4 types, the most common type is nodular ulcer. 1. Nodular ulcer type: At first, there were waxy nodules about the size of a grain of rice to peas on the epidermis, which were hard in texture, with a few dilated capillaries on the surface, slightly higher than the skin surface, or just like erythema without swelling, or slightly nodular, and the surface skin was slightly depressed downward. Nodules can gradually expand or appear new lesions, and merge with each other to form disc-shaped plaques with waxy luster. Brown, tan or dark gray scars often form in the center, and then ulcers occur under the scab, which gradually expand to form round, oval or plastic ulcers, ranging in size from rings to copper coins. The edge of the ulcer is solid, rolled up, often translucent and uneven, and the surrounding skin is not inflamed. The bottom is pearly or waxy, and sometimes the damaged surface is completely scabbed. Ulcer slowly spreads to the periphery and deep, such as rat bite, forming a typical clinical form of basal cell carcinoma, so it is called erosive ulcer. Ulcer can partially heal and scar, or spread to subcutaneous tissue, even cartilage and bones. All kinds of tissues can be destroyed into deep pits. Occurring on the face can destroy the cartilage and bone tissue of the nose, ears, orbit and maxillary sinus, causing bleeding or intracranial invasion or disfigurement. 2. Pigmented type: Nodules are flat and shallow, and the damage is the same as nodular ulcer type. Because it contains a lot of pigments, the damaged edges are dotted or reticulated dark brown or dark brown pigment spots besides pearl luster, and pigmentation can also be seen in the central part. It is easy to bleed when the scab is uncovered, and it can be dark brown or even carbon black particles under the scab, which is similar to malignant melanoma and easy to be misdiagnosed. 3. Hard spot or fibrotic type: it occurs in the head and neck, showing hard yellowish or yellowish-white spots, slightly raised, with unclear boundaries, resembling hard spot disease, which can remain intact for a long time and finally fester. 4. Superficial type: The skin lesions are superficial, mostly occurring in the trunk, showing as one or several pieces of infiltrating erythema, with desquamation or scabbing on the surface, and the edges or the whole skin lesions are slightly raised, at least part of the edges are in the shape of small pearls or linear dikes. This type will eventually fibrosis. Similar to psoriasis, eczema or seborrheic dermatitis. The damage of basal cell carcinoma develops slowly, with few regional lymph node metastasis and no distant metastasis. Treatment: 1, surgical treatment Early operation, for larger tumors and well-differentiated patients, surgical resection is the first choice, and pay attention to the width and depth of the incision. X-rays should be taken after the operation, and the samples taken out should be sent to the disease examination. 2. Other therapies such as carbon dioxide, electrocautery and liquid nitrogen freezing are effective. Prescriptions and remedies: ① Radix Isatidis120g, Flos Lonicerae 9g, Fructus Forsythiae 9g and Fructus Gleditsiae Abnormalis 9g. Daily 1 dose, decocted twice, divided into eyes. Efficacy: Many cases were treated by Formula F, and the curative effect was remarkable. Cured after 2.5 months 1 case. ② Venenum Bufonis ointment: 20% Venenum Bufonis ointment was prepared by dissolving Venenum Bufonis 10g in 30ml washing solution and adding 40g sulfanilamide ointment. Generally, the drug was used for 3 days, and about 18 days later, the cancer tissue began to fall off and basically healed. Efficacy: Qingdao Bethune Hospital cured 3 cases of skin cancer/kloc-0. Prescription ① Zhangru powder: 30g of Plumbum preparatium and 0/0g of frankincense/kloc. Grind sesame oil into paste and apply it to the affected area, once a day/kloc-0. ② 30g Hedyotis diffusa and 30g Prunella vulgaris. Astragalus membranaceus 30g, Paris polyphylla 15g, Daqujia 10g, Glycyrrhiza uralensis Fisch 10g. Decoct with water twice a day.