Of course, the therapeutic effect of drugs for external use is very limited, and long-term use may have certain effect, but the effect is limited; 2. In addition to medical treatment, that is, surgical intervention, surgical treatment also includes micro-plastic surgery, that is, local wrinkle removal needles can be used, and wrinkles can be removed after using wrinkle removal needles. The principle of action is to prevent nerve and muscle joints through botulinum toxin A and release acetylcholine, so that the wrinkled muscles of the expression muscles will not contract and the wrinkles will naturally flatten; 3. There is also a micromachining method, that is, local injection filling hyaluronic acid, that is, filling wrinkles to make sodium hyaluronate full, which will not be too obvious; 4. In addition to this micro-plastic surgery, there is also a face-lifting surgery, which makes an incision to tighten the skin, so that wrinkles can be removed.