Dexamethasone acetate tablets Chinese phonetic name: Dexamethasone acetate tablets English name: Dexamethasone acetate tablets page number. : Dexamethasone acetate (C24H3 1FO6) in version II-10/9 of 2000 should be 90.0% ~10.0. Characteristics This product is a white tablet. Identification Take a proper amount of fine powder of this product (about 7mg of dexamethasone acetate), add 25ml of ethanol, soak it for 65438 05 minutes, shake it evenly from time to time, filter it, put the filtrate in a water bath to dry, and the residue shows organic fluoride identification reaction (Appendix 3). Check the content uniformity Take 65438 0 tablets of this product, put them in a mortar, grind them, add a proper amount of ethanol, grind them, transfer them to a 50ml volumetric flask containing 40ml ethanol, place them in a water bath at 50 ~ 60℃ for 65438 00 minutes, shake them evenly from time to time to dissolve dexamethasone acetate, cool them to room temperature, dilute them with ethanol to scale, shake them evenly, filter them, and take continuous filtrate. The absorbance was measured at the wavelength of 240nm. According to the absorption coefficient of C24H31Fo6 (E1%1cm+0 cm), the content was 357, which should meet the requirements (Appendix XE). Others shall comply with the relevant regulations under tablets (appendix 1A). Content determination: Take 20 tablets of this product, accurately weigh them, finely grind them, accurately weigh an appropriate amount (about 7.5mg of dexamethasone acetate), put them in a 100ml volumetric flask, add 75ml ethanol, keep them in a water bath at 50 ~ 60℃ for 10 min, shake them evenly to dissolve dexamethasone acetate, cool them to room temperature, and dilute them with ethanol. Put it in another 100ml volumetric flask, add ethanol to the scale, shake well, measure the absorbance at 240nm according to the spectrophotometry (Appendix ⅳA), and calculate the absorption coefficient (E 1% 1cm+0 cm) of C24H3 1FO6 as 357. The category is the same as dexamethasone acetate. Specification: 0.75mg, sealed and stored away from light. The main component of this product is dexamethasone acetate. Its chemical name is 16a- methyl-1 1b, 17a, 2 1- trihydroxy -9a- fluoropgesterone-1, 4- diene-3,20. Structural formula: molecular formula: C24H3 1FO6 Molecular weight: 434.50 Pharmacology and toxicology Adrenal corticosteroids have more obvious anti-inflammatory, anti-allergic and anti-shock effects than prednisone, but have less influence on water and sodium retention and potassium excretion, and have stronger inhibitory effect on pituitary-adrenal gland. 1. Anti-inflammatory effect: This product can reduce and prevent the reaction of tissues to inflammation, thus reducing the manifestations of inflammation. Hormones inhibit the aggregation and phagocytosis of inflammatory cells (including macrophages and leukocytes), the release of lysosomal enzymes and the synthesis and release of inflammatory chemical mediators. It can reduce and prevent the reaction of tissues to inflammation, thus reducing the manifestations of inflammation. 2. Immunosuppression: including preventing or inhibiting cell-mediated immune response and delayed allergic response, reducing the number of T lymphocytes, monocytes and eosinophils, reducing the binding ability of immunoglobulin to cell surface receptors, and inhibiting the synthesis and release of interleukin, thus reducing the transformation of T lymphocytes to lymphocytes and alleviating the expansion of primary immune response. Can reduce the immune complex through the basement membrane, and can reduce the concentration of complement components and immunoglobulin. Pharmacokinetics This product is easily absorbed from the digestive tract. The plasma T 1/2 was 190 minutes, and the tissue T 1/2 was 3 days. Plasma protein binding rate is lower than other corticosteroids. Indications are mainly used for allergic and autoimmune inflammatory diseases. Such as connective tissue disease, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia and malignant lymphoma. In addition, this drug is also used in the diagnosis of some adrenal cortical diseases-dexamethasone inhibition test. Usage and dosage: the initial dose for adults is 0.75~3.00mg( 1~4 tablets) once, 2~4 times a day. The maintenance dose is about 0.75 mg per day (1tablet), depending on the condition. Adverse reactions This product is easy to cause diabetes, peptic ulcer and Cushing's syndrome in large doses, and has a strong inhibitory effect on hypothalamus-pituitary-adrenal axis. Concurrent infection is the main adverse reaction. Contraindications: it is forbidden for those who have allergic history to this product and adrenocortical drugs. Patients with hypertension, thrombosis, gastric and duodenal ulcer, psychosis, abnormal electrolyte metabolism, myocardial infarction, visceral surgery, glaucoma, etc. Usually not suitable for use. Weigh the pros and cons under special circumstances. Precautions 1. Patients with pulmonary tuberculosis, acute bacterial or viral infection should be treated with caution, and appropriate anti-infection treatment must be given when necessary. 2. After taking the medicine for a long time, it should be gradually reduced and then stopped. 3. Use with caution in patients with diabetes, osteoporosis, liver cirrhosis, renal insufficiency and hypothyroidism. The use of drugs by pregnant women and lactating women during pregnancy will increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. Animal experiments have teratogenic effects, so we should weigh the advantages and disadvantages. Breast-feeding mothers should not breast-feed if they receive large doses of drugs, so as to avoid adverse reactions such as infant growth inhibition and adrenal function inhibition caused by drugs discharged through milk. Children should be very cautious when using adrenocortical hormone, which will inhibit children's growth and development. If long-term use is really necessary, short-acting or medium-acting preparations should be selected, and long-acting dexamethasone preparations should be avoided. Observe the changes of intracranial pressure. Elderly patients are prone to hypertension, and elderly patients, especially postmenopausal women, are prone to osteoporosis. Drug interaction 1. When taken together with barbiturates, phenytoin and rifampicin, the metabolic promotion of this product is weakened. 2. Combine with salicylic acid drugs to increase their toxicity. 3. It can weaken the effect of anticoagulants and oral hypoglycemic agents, and the dosage should be adjusted. 4. Combined with diuretics (except potassium-preserving diuretics) can cause hypokalemia, so pay attention to the dosage.

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