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Is it harmful to pull out 4 teeth in the whole tooth?
This situation is harmless.

Because the teeth usually extracted are bilateral maxillary first premolars and mandibular first premolars. Because pulling out these four teeth will not cause the loss of oral function, nor will it affect the pronunciation and eating function of language, and the corresponding gaps will be closed after orthodontic treatment, so pulling out these four teeth will have little or no impact on the future.