3,245.7 kilometers. Baidu map shows that Urumqi is located in the northwest of China, in the middle of Xinjiang, in the hinterland of Eurasia, and Guiyang is located in the middle and southwest of Guizhou, with a distance of 3,245.7 kilometers. Driving takes 1 day, 14 hours, passing Lianhuo Expressway and Lanhai Expressway.